CPC A61K 31/198 (2013.01) [A61K 47/54 (2017.08); A61K 47/545 (2017.08); A61K 47/548 (2017.08); A61K 47/549 (2017.08); A61P 1/16 (2018.01)] | 4 Claims |
1. A compound containing a liver targeting specific ligand and a thyroid hormone receptor agonist in the structure, wherein the liver targeting specific ligand X is connected to the thyroid hormone receptor agonist T sequentially through a branched chain L containing a structure for stabilizing steric hindrance, a linker B and a linking chain D, and the compound is represented by Formula (I) of
(X-L)n-B-D-T
wherein n is 3, Formula (I) has a structure as shown below:
the compound has one of the structures shown in Kylo-0101 to Kylo-0103:
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