CPC A61B 5/08 (2013.01) [A61B 5/082 (2013.01); A61B 5/097 (2013.01); A61B 5/411 (2013.01); A61B 2562/028 (2013.01); G01N 33/497 (2013.01); G01N 2030/025 (2013.01); G01N 2033/4975 (2013.01)] | 20 Claims |
1. A method for detecting whether a subject has a respiratory disease or for monitoring a subject with a respiratory disease, the method comprising:
receiving, at a portable apparatus having a gas chromatograph coupled to a detector array, ambient air to be inhaled by the subject, wherein the portable apparatus includes the gas chromatograph and the detector array replaceably mounted to a substrate of the portable apparatus;
filtering, by a volatile organic compound (VOC) filter, the ambient air to remove at least a portion of background VOC content in the ambient air;
further filtering, by a nitric oxide (NO) filter, the ambient air to remove at least a portion of background NO content from the ambient air;
providing, at the portable apparatus, at least a portion of the ambient air to the subject to be inhaled;
receiving, at the portable apparatus, breath exhaled from the subject;
contacting the breath exhaled from the subject with the gas chromatograph mounted to the substrate of the portable apparatus;
producing, by the detector array coupled to the gas chromatograph and mounted to the substrate of the portable apparatus, an indicator based on the exhaled breath from the subject, the indicator being produced based at least in part on one or more analytes in the breath exhaled from the subject, and the indicator being indicative of one or more biomarkers in the exhaled breath; and
analyzing, by an analysis circuit disposed on the portable apparatus, the indicator to determine whether the subject has the respiratory disease, wherein the determination is made based on an NO concentration level in conjunction with VOC detection from the breath exhaled from the subject.
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