US 11,690,524 B2
Assessment of iron deposition post myocardial infarction as a marker of myocardial hemorrhage
Rohan Dharmakumar, Moorpark, CA (US); and Ivan Cokic, Los Angeles, CA (US)
Assigned to Cedars-Sinai Medical Center, Los Angeles, CA (US)
Filed by Cedars-Sinai Medical Center, Los Angeles, CA (US)
Filed on Jun. 18, 2020, as Appl. No. 16/905,702.
Application 16/905,702 is a continuation of application No. 15/064,817, filed on Mar. 9, 2016, granted, now 10,694,962.
Application 15/064,817 is a continuation in part of application No. 14/125,307, granted, now 10,694,961, previously published as PCT/US2012/042310, filed on Jun. 13, 2012.
Claims priority of provisional application 61/496,441, filed on Jun. 13, 2011.
Prior Publication US 2020/0315468 A1, Oct. 8, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/127 (2006.01); A61B 5/026 (2006.01); A61B 5/00 (2006.01); G16H 50/30 (2018.01); G16H 20/10 (2018.01); G16H 30/40 (2018.01); A61K 49/06 (2006.01)
CPC A61B 5/0263 (2013.01) [A61B 5/0044 (2013.01); A61B 5/4848 (2013.01); A61B 5/7275 (2013.01); G16H 20/10 (2018.01); G16H 50/30 (2018.01); A61K 49/06 (2013.01); G16H 30/40 (2018.01); Y02A 90/10 (2018.01)] 18 Claims
 
1. A method for treating a subject with myocardial infarction, comprising:
administering to the subject an effective amount of a composition comprising a chelating agent, at least in chronic phase of the myocardial infarction, based on knowledge of an increase in iron oxide deposition in the chronic phase in the infarcted region relative to a remote region following reperfusion hemorrhage,
wherein the subject has undergone reperfusion following the myocardial infarction, the subject has hemorrhage in the myocardial infarct, and
the subject has been detected to have an increase in iron oxide deposition in a hemorrhagic infarcted region of the subject's heart relative to the remote region of the subject's heart.