US 11,686,722 B2
Compositions and methods to detect molecules in a sample
Edward Chaum, Memphis, TN (US); and Erno Linder, Memphis, TN (US)
Assigned to INFUSENSE CORP., Nashville, TN (US)
Appl. No. 16/470,373
Filed by Infusense Corp., Memphis, TN (US)
PCT Filed Dec. 18, 2017, PCT No. PCT/US2017/066997
§ 371(c)(1), (2) Date Jun. 17, 2019,
PCT Pub. No. WO2018/112458, PCT Pub. Date Jun. 21, 2018.
Claims priority of provisional application 62/435,530, filed on Dec. 16, 2016.
Prior Publication US 2019/0331656 A1, Oct. 31, 2019
Int. Cl. G01N 33/487 (2006.01); G01N 27/327 (2006.01); G01N 27/403 (2006.01); G01N 33/94 (2006.01)
CPC G01N 33/48707 (2013.01) [G01N 27/3275 (2013.01); G01N 27/403 (2013.01); G01N 33/948 (2013.01)] 35 Claims
OG exemplary drawing
 
1. A non-invasive device for detecting at least one electrochemically active molecule in a fluid sample of a subject, the device comprising a non-invasive, electrochemical, voltammetric sensor comprising two or more electrodes, wherein at least one end of the electrodes is in direct contact with a water-immiscible coating which has hydrophobic properties and is configured to selectively partition the electrochemically active molecule from the fluid sample, wherein a voltammetric signal is generated sublingually by the sensor in the presence of an electrochemically active molecule in the fluid sample, wherein the sensor comprises a sublingual sensor.