CPC C07K 16/2845 (2013.01) [A61K 38/1774 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61K 47/59 (2017.08); A61K 47/643 (2017.08); A61P 37/06 (2018.01); C07K 14/705 (2013.01); C07K 14/70503 (2013.01); A61K 38/00 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/76 (2013.01); C07K 2319/70 (2013.01)] | 13 Claims |
1. A method of treating a disease associated with immune suppression, comprising administering a composition to a subject in need thereof, inhibiting PD-L1 expression, and reversing immune suppression or immune exhaustion in the subject, thereby treating a disease associated with immune suppression, wherein the composition comprises an antibody or antigen-binding portion thereof comprising:
(i) a heavy chain variable region comprising H-CDR1 having the sequence of SEQ ID NO:1, H-CDR2 having the sequence of SEQ ID NO:3, and H-CDR3 having the sequence of SEQ ID NO:5; or a heavy chain variable region comprising H-CDR1 having the sequence of SEQ ID NO:2, H-CDR2 having the sequence of SEQ ID NO:4, and H-CDR3 having the sequence of SEQ ID NO:6; and
(ii) a light chain variable region comprising L-CDR1 having the sequence of SEQ ID NO:7, L-CDR2 having the sequence of SEQ ID NO:9, and L-CDR3 having the sequence of SEQ ID NO:11; or a light chain variable region comprising L-CDR1 having the sequence of SEQ ID NO:8, L-CDR2 having the sequence of SEQ ID NO:10, and L-CDR3 having the sequence of SEQ ID NO:12.
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