CPC C07K 16/2809 (2013.01) [A61P 35/00 (2018.01); C07K 16/2803 (2013.01); C07K 16/2815 (2013.01); C07K 16/2866 (2013.01); C07K 16/30 (2013.01); C07K 16/3038 (2013.01); C07K 16/3061 (2013.01); A61K 2039/505 (2013.01); A61K 2039/545 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/622 (2013.01); C07K 2317/626 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01)] | 33 Claims |
1. A Disease Antigen×CD3 (DA×CD3) Binding Molecule comprising a CD3-Binding Domain capable of binding an epitope of CD3 and a Disease Antigen-Binding Domain capable of binding an epitope of CD123, wherein said CD3-Binding Domain comprises:
(A) a CDRH1 Domain comprising the amino acid sequence of SEQ ID NO:99;
(B) a CDRH2 Domain comprising the amino acid sequence of SEQ ID NO:58;
(C) a CDRH3 Domain comprising the amino acid sequence of SEQ ID NO:59;
(D) a CDRL1 Domain comprising the amino acid sequence of SEQ ID NO:60;
(E) a CDRL2 Domain comprising the amino acid sequence of SEQ ID NO:61; and
(F) a CDRL3 Domain comprising the amino acid sequence of SEQ ID NO:62.
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