CPC C07K 1/22 (2013.01) [B01D 15/3809 (2013.01); B01J 20/24 (2013.01); B01J 20/286 (2013.01); B01J 20/28016 (2013.01); B01J 20/28078 (2013.01); B01J 20/3212 (2013.01); B01J 20/3274 (2013.01); C07K 14/31 (2013.01); C07K 16/00 (2013.01); C07K 16/065 (2013.01); C07K 17/10 (2013.01)] | 40 Claims |
1. A separation matrix comprising at least 15 mg/ml Fc-binding ligands covalently coupled to a porous support, wherein:
a) said ligands comprise multimers of alkali-stabilized Protein A domains,
b) said porous support comprises cross-linked polymer particles having a volume-weighted median diameter (d50, v) of from 56 micrometers to 70 micrometers and a dry solids weight of from 55 mg/ml to 80 mg/ml.
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