US 11,685,761 B2
Cyclic di-nucleotide compounds as sting agonists
Brian M. Andresen, Sharon, MA (US); Frank Bennett, Cranford, NJ (US); Wonsuk Chang, Princeton, NJ (US); Matthew Lloyd Childers, Medfield, MA (US); Jared N. Cumming, Winchester, MA (US); Jongwon Lim, Lexington, MA (US); Min Lu, Brookline, MA (US); Benjamin Wesley Trotter, Medfield, MA (US); and Wen-Lian Wu, Green Brook, NJ (US)
Assigned to Merck Sharp & Dohme LLC, Rahway, NJ (US)
Appl. No. 16/771,814
Filed by Merck Sharp & Dohme Corp., Rahway, NJ (US); Brian M. Andresen, Sharon, MA (US); Frank Bennett, Cranford, NJ (US); Wonsuk Chang, Princeton, NJ (US); Matthew Lloyd Childers, Medfield, MA (US); Jared N. Cumming, Winchester, MA (US); Jongwon Lim, Lexington, MA (US); Min Lu, Brookline, MA (US); Benjamin Wesley Trotter, Medfield, MA (US); and Wen-Lian Wu, Green Brook, NJ (US)
PCT Filed Dec. 17, 2018, PCT No. PCT/US2018/065902
§ 371(c)(1), (2) Date Jun. 11, 2020,
PCT Pub. No. WO2019/125974, PCT Pub. Date Jun. 27, 2019.
Claims priority of provisional application 62/608,154, filed on Dec. 20, 2017.
Prior Publication US 2021/0206796 A1, Jul. 8, 2021
Int. Cl. C07H 21/00 (2006.01); A61P 37/04 (2006.01); C07H 21/02 (2006.01); A61K 31/7084 (2006.01); C07H 21/04 (2006.01)
CPC C07H 21/00 (2013.01) [A61K 31/7084 (2013.01); A61P 37/04 (2018.01); C07H 21/02 (2013.01); C07H 21/04 (2013.01); C07B 2200/07 (2013.01)] 20 Claims
 
1. A compound of formula (I):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein
Base1 and Base2 are each independently selected from the group consisting of

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry
wherein
at least one of Base1 and Base2 is each independently selected from the group consisting of

OG Complex Work Unit Chemistry
and
Base1 and Base2 each may be independently substituted by 0-3 substituents R10, where each R10 is independently selected from the group consisting of F, Cl, I, Br, OH, SH, NH2, C1-3 alkyl, C3-6 cycloalkyl, O(C1-3 alkyl), O(C3-6 cycloalkyl), S(C1-3 alkyl), S(C3-6 cycloalkyl), NH(C1-3 alkyl), NH(C3-6 cycloalkyl), N(C1-3 alkyl)2, and N(C3-6 cycloalkyl)2;
Y and Ya are each independently selected from the group consisting of —S—, —SO2—, —CH2—, and —CF2—;
Xa and Xa1 are each independently selected from the group consisting of —O—, —S—, and —CH2—;
Xb and Xb1 are each independently selected from the group consisting of —O—, —S—, and —CH2—;
Xc and Xc1 are each independently selected from the group consisting of —SR9, —OR9, and —NR9R9,
Xd and Xd1 are each independently selected from the group consisting of O and S;
R1 and R1a are each independently selected from the group consisting of H, F, Cl, Br, I, OH, CN, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl, where said R1 and R1a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N3;
R2 and R2a are each independently selected from the group consisting of H, F, Cl, Br, I, OH, CN, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl, where said R2 and R2a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N3;
R3 is selected from the group consisting of H, F, Cl, Br, I, OH, CN, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl, where said R3 C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N3;
R4 and R4a are each independently selected from the group consisting of H, F, Cl, Br, I, OH, CN, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl, where said R4 and R4a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N3;
R5 is selected from the group consisting of H, F, Cl, Br, I, OH, CN, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl, where said R5 C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N3;
R6 and R6a are each independently selected from the group consisting of H, F, Cl, Br, I, OH, CN, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl, where said R6 and R6′ C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N3;
R7 and R7a are each independently selected from the group consisting of H, F, Cl, Br, I, OH, CN, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl, where said R7 and R7a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N3;
R8 and R8a are each independently selected from the group consisting of H, F, Cl, Br, I, OH, CN, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl, where said R8 and R8a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N3;
each R9 is independently selected from the group consisting of H, C1-C20 alkyl,

OG Complex Work Unit Chemistry
where each R9 C1-C20 alkyl is optionally substituted by 0 to 3 substituents independently selected from the group consisting of OH, —O—C1-C20 alkyl, —S—C(O)C1-C6 alkyl, and C(O)OC1-C6 alkyl;
optionally R1a and R3 are connected to form C1-C6 alkylene, C2-C6 alkenylene, —O—C1-C6 alkylene, or —O—C2-C6 alkenylene, such that where R1a and R3 are connected to form —O—C1-C6 alkylene, or —O—C2-C6 alkenylene, said O is bound at the R3 position;
optionally R2a and R3 are connected to form C1-C6 alkylene, C2-C6 alkenylene, —O—C1-C6 alkylene, or —O—C2-C6 alkenylene, such that where R2a and R3 are connected to form —O—C1-C6 alkylene, or —O—C2-C6 alkenylene, said O is bound at the R3 position;
optionally R3 and R6′ are connected to form C1-C6 alkylene, C2-C6 alkenylene, —O—C1-C6 alkylene, or —O—C2-C6 alkenylene, such that where R3 and R6′ are connected to form —O—C1-C6 alkylene, or —O—C2-C6 alkenylene, said O is bound at the R3 position;
optionally R4 and R5 are connected to form C1-C6 alkylene, C2-C6 alkenylene, —O—C1-C6 alkylene, or —O—C2-C6 alkenylene, such that where R4 and R5 are connected to form —O—C1-C6 alkylene, or —O—C2-C6 alkenylene, said O is bound at the R5 position;
optionally R5 and R6 are connected to form —O—C1-C6 alkylene, —O—C2-C6 alkenylene, or —O—C2-C6 alkynylene, such that where R5 and R6 are connected to form C1-C6 alkylene, —O—C2-C6 alkenylene, or —O—C2-C6 alkynylene, said O is bound at the R5 position;
optionally R7 and R8 are connected to form C1-C6 alkylene or C2-C6 alkenylene; and
optionally R7a and R8a are connected to form C1-C6 alkylene or C2-C6 alkenylene.