US 11,685,760 B2
Amino acid derivative of glucosamine stimulating extracellular matrix synthesis and pharmaceutical composition comprising the same
Filippo Surace, Otranto (IT); and Roberto Scandurra, Rome (IT)
Assigned to CARTILAGO S.R.L., Maglie (IT)
Appl. No. 17/277,876
Filed by CARTILAGO S.R.L., Maglie (IT)
PCT Filed Sep. 19, 2019, PCT No. PCT/IB2019/057896
§ 371(c)(1), (2) Date Mar. 19, 2021,
PCT Pub. No. WO2020/058889, PCT Pub. Date Mar. 26, 2020.
Claims priority of application No. 102018000008758 (IT), filed on Sep. 20, 2018.
Prior Publication US 2021/0347803 A1, Nov. 11, 2021
Int. Cl. A61K 31/7008 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); C07H 15/207 (2006.01)
CPC C07H 15/207 (2013.01) [A61K 9/00 (2013.01); A61K 9/0019 (2013.01); A61K 9/06 (2013.01); A61K 31/7008 (2013.01)] 19 Claims
 
1. A pharmaceutical composition suitable for parenteral administration route comprising an amino acid derivative of glucosamine having the following Formula 1 of general structure:

OG Complex Work Unit Chemistry
or the pharmaceutically acceptable salt, solvate, hydrate or stereoisomer thereof, wherein the group R represents an amino acid, an N-acyl derivative of an amino acid or an N-acyl derivative of a peptide and wherein the amine group of glucosamine is bound by amide bond to the carboxyl side chain of said amino acid; wherein the pharmaceutical composition comprises the amino acid derivative of glucosamine at a concentration of between 0.5% by weight and 4.5% by weight, together with carriers suitable for said administration route.