CPC C07D 519/00 (2013.01) | 8 Claims |
1. A compound of Formula Ia:
or a pharmaceutically acceptable salt, stereoisomer, tautomer, or oxepane isomer thereof, wherein:
R32 is H, ═O, —OR3, or —N3;
A3 is —[C(R3)2]n—, (C6-C10)arylene, cycloalkylene, heteroarylene, or heterocyclylene;
R26 is -A1-L1-A2-B; -A1-A2-B; or -L2-A1-L1-A2-L3-B;
A1 and A2 are independently absent or are independently selected from
wherein the bond on the left side of A1, as drawn, is bound to —C(═O)— or L2; and wherein the bond on the right side of the A2 moiety, as drawn, is bound to B or L3;
each Q is independently 1 to 3 rings selected from arylene, cycloalkylene, heteroarylene, and heterocyclylene;
each X is independently absent or 1 to 2 rings selected from arylene, cycloalkylene, heteroarylene, and heterocyclylene;
each X1 is independently a heteroarylene or heterocyclylene ring;
each W is independently absent or 1 to 2 rings selected from arylene, cycloalkylene, heteroarylene, and heterocyclylene;
each W1 is independently a heteroarylene or heterocyclylene ring;
each G is independently absent or a ring selected from arylene, cycloalkylene, heteroarylene, and heterocyclylene;
each G1 and G2 are independently heteroarylene or heterocyclylene ring;
each L1 is independently selected from
L2 and L3 are independently absent or are independently selected from
each B is independently selected from
each B1 is independently selected from
wherein the
bond on the left side of B1, as drawn, is bound to A2 or L1; and wherein the heteroarylene, heterocyclylene, and arylene are each independently optionally substituted with alkyl, hydroxyalkyl, haloalkyl, alkoxy, halogen, or hydroxyl;
each R3 is independently H or (C1-C6)alkyl;
each R4 is independently H, (C1-C6)alkyl, halogen, 5-12 membered heteroaryl, 5-12 membered heterocyclyl, (C6-C10)aryl, wherein the heteroaryl, heterocyclyl, and aryl are each independently optionally substituted with —N(R3)2, —OR3, halogen, (C1-C6)alkyl, —(C1-C6)alkylene-heteroaryl, -(C1-C6)alkylene-CN, —C(O)NR3-heteroaryl, or —C(O)NR3-heterocyclyl;
each R5 is independently H, (C1-C6)alkyl, —C(O)OR3, or —N(R3)2, wherein the alkyl of (C1-C6)alkyl is optionally substituted with —N(R3)2 or —OR3;
each R6 is independently H, (C1-C6)alkyl, —C(O)OR3, or —N(R3)2, wherein the alkyl of (C1-C6)alkyl is optionally substituted with —N(R3)2 or —OR3;
each R7 is independently H, (C1-C6)alkyl, —C(O)OR3, or —N(R3)2, wherein the alkyl of (C1-C6)alkyl is optionally substituted with —N(R3)2 or —OR3;
each R8 is independently H, (C1-C6)alkyl, —C(O)OR3, or —N(R3)2, wherein the alkyl of (C1-C6)alkyl is optionally substituted with —N(R3)2 or —OR3;
each Y is independently C(R3)2 or a bond;
each n is independently an integer from one to 12;
each o is independently an integer from zero to 30;
each p is independently an integer from zero to 12;
each q is independently an integer from zero to 30; and
each r is independently an integer from one to 6.
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