CPC C07D 413/14 (2013.01) [C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01)] | 35 Claims |
1. A compound of Formula I:
or a pharmaceutically acceptable salt, stereoisomer, or mixture of stereoisomers thereof;
wherein:
ring B is a heterocycloalkyl ring optionally having 1 to 3 additional heteroatoms selected from O, N, and S;
X is CH or N;
(i) Z is N and Y is —CH(R1)— or —CH2—; or
(ii) Z—Y is —C═C(R1)— or —C═C(H)—;
L is C1-3 alkylene optionally substituted with C1-4alkoxy;
each R1 is independently C1-4alkyl, halo-C1-4alkyl, C1-4alkoxy, halo-C1-4alkoxy, or C3-6 cycloalkyl;
or two R1, together with the carbon atoms to which they are attached, join to form a cycloalkyl ring;
each R2 is independently selected from hydroxy, halo, C1-4alkyl optionally substituted with C1-4alkoxy, halo-C1-4alkyl optionally substituted with C1-4alkoxy, C1-4alkoxy optionally substituted with cycloalkyl, halo-C1-4alkoxy, C3-6 cycloalkyl, and C3-6 cycloalkoxy;
or two R2, when present on the same carbon atom, join to form oxo;
or two R2, together with the carbon atoms to which they are attached, join to form a C3-7 cycloalkyl ring optionally substituted with 1 to 3 halo or a 3- to 7-membered heterocycloalkyl ring optionally substituted with 1 to 3 halo, wherein the heterocycloalkyl ring contains 1 to 3 heteroatoms selected from N, O, and S;
R3 is H or C1-6alkyl optionally substituted with —N(R8)(R9), C1-4alkoxy, or C3-6 cycloalkyl;
R4 is H or halo;
R5 is an aryl or 5- to 10-membered heteroaryl having 1, 2, 3, or 4 heteroatoms selected from N, O, and S, each of which is optionally substituted with 1 to 3 R6;
each R6 is independently halo, C1-6alkyl, halo-C1-6alkyl, or —OR7;
each R7 is independently selected from heterocycloalkyl and C1-6alkyl optionally substituted with C1-4alkoxy or halo;
R8 and R9 are each independently selected from H and C1-6alkyl;
p is 0, 1, 2, or 3; and
m is 0, 1, 2, or 3.
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