CPC C07D 401/06 (2013.01) [A61K 45/06 (2013.01); C07D 211/34 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01)] | 29 Claims |
1. A compound of Formula I,
wherein,
the dash line is a bond that is present or absent;
n is 0, 1, or 2;
Ar is phenyl, pyridinyl, pyrimidinyl, or pyrazinyl;
R1 is C1-C8 alkyl, C3-C6 cycloalkyl, or C6 aryl, and of which is optionally substituted with one or more groups chosen from halo, hydroxyl, cyano, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxyl, C1-C6 haloalkoxyl, C3-C6 cycloalkyl, C3-C6 heterocycloalkyl, C6 aryl, heteroaryl, OCH2-C6 aryl, or O—CH2-heteroaryl;
R2 is halo, OH, C1-C8 alkyl, C1-C8 alkoxyl, C6 aryl, O—C6 aryl, heteroaryl, O-heteroaryl, O—CH2-C6 aryl, or O—CH2-heteroaryl; and
R3 is CH2OH, CO2H, CO2-C1-C6 alkyl, CO2-C3-C6 cycloalkyl, or CO2-C1-C6 heteroalkyl,
or a pharmaceutically acceptable salt thereof.
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