US 11,684,914 B2
Method of transferring material from microfabricated device
Alexander Hallock, San Carlos, CA (US); Peter Christey, San Carlos, CA (US); Jude Dunne, San Carlos, CA (US); Marc Glazer, San Jose, CA (US); Benjamin Lane, Hydes, MD (US); Joshua Gomes, Cambridge, MA (US); Shreyas Ashok, Apex, NC (US); and Shao Ning Pei, San Carlos, CA (US)
Assigned to ISOLATION BIO INC., San Carlos, CA (US)
Filed by General Automation Lab Technologies Inc., San Carlos, CA (US)
Filed on Feb. 18, 2021, as Appl. No. 17/179,380.
Claims priority of provisional application 62/978,271, filed on Feb. 18, 2020.
Prior Publication US 2021/0252500 A1, Aug. 19, 2021
Int. Cl. B01L 3/00 (2006.01); G01N 35/10 (2006.01)
CPC B01L 3/5025 (2013.01) [B01L 3/563 (2013.01); G01N 35/1074 (2013.01); G01N 35/1081 (2013.01); B01L 2200/025 (2013.01); B01L 2200/026 (2013.01); B01L 2200/141 (2013.01); B01L 2300/0819 (2013.01); B01L 2300/0829 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method of transferring material from a first device comprising an upper surface including a first array of microwells to a second device comprising an upper surface, wherein at least one of the first array of microwells contain at least one cell, the method comprising:
securing an assembly comprising the first device and the second device in a mounting structure, wherein the first device and the second device are positioned in a way that the upper surface of the second device is opposite the upper surface of the first device and the relative positions of the first device and the second device are fixed; and
moving the mounting structure carrying the first device and the second device toward a stopper plate, the stopper plate having an initial position apart from the mounting structure, until the assembly or a part of the mounting structure contacts the stopper plate, wherein the speed of the mounting structure immediately before the contact is sufficient to cause the transfer of at least a portion of the well content of the at least one of the first array of microwells of the first device to the upper surface of the second device.