US 11,684,700 B2
Composite material for tissue restoration
Xuesong Jiang, Lutherville, MD (US); Sashank Reddy, Baltimore, MD (US); Gerald Brandacher, Baltimore, MD (US); Hai-Quan Mao, Baltimore, MD (US); Justin Sacks, Baltimore, MD (US); Xiaowei Li, Towson, MD (US); Kevin Feng, Baltimore, MD (US); Russell Martin, Baltimore, MD (US); Georgia C. Yalanis, Baltimore, MD (US); and Ji Suk Choi, Baltimore, MD (US)
Assigned to The Johns Hopkins University, Baltimore, MD (US)
Filed by The Johns Hopkins University, Baltimore, MD (US)
Filed on Jun. 23, 2022, as Appl. No. 17/847,832.
Application 17/847,832 is a continuation of application No. 16/533,375, filed on Aug. 6, 2019.
Application 16/533,375 is a continuation of application No. 15/432,606, filed on Feb. 14, 2017, granted, now 10,463,768, issued on Nov. 5, 2019.
Application 15/432,606 is a continuation of application No. PCT/US2015/045494, filed on Aug. 17, 2015.
Claims priority of provisional application 62/038,030, filed on Aug. 15, 2014.
Prior Publication US 2022/0339321 A1, Oct. 27, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/52 (2006.01); A61L 27/16 (2006.01); A61L 27/24 (2006.01); A61L 27/36 (2006.01); A61L 27/56 (2006.01); A61L 27/58 (2006.01); A61L 27/18 (2006.01); A61L 27/48 (2006.01)
CPC A61L 27/52 (2013.01) [A61L 27/16 (2013.01); A61L 27/18 (2013.01); A61L 27/24 (2013.01); A61L 27/3633 (2013.01); A61L 27/56 (2013.01); A61L 27/58 (2013.01); A61L 27/48 (2013.01); A61L 2400/06 (2013.01); A61L 2430/06 (2013.01); A61L 2430/34 (2013.01)] 25 Claims
 
1. A scaffold complex comprising:
a polymeric fiber comprising collagen;
a hydrogel material comprising hyaluronic acid;
a crosslinking moiety present in an amount effective to introduce interfacial bonding between the polymeric fiber and the hydrogel material; and
a plurality of pores present on a surface of the scaffold complex, wherein the pores are present at a concentration of at least about 50 pores per cm2 of the surface, and wherein at least 80% of the pores have an average pore diameter on the surface that is at least about 5 microns,
wherein the scaffold complex is suitable for incorporation into the tissue of a human subject by injection of the scaffold complex into the tissue.