CPC A61L 27/446 (2013.01) [A61L 24/0084 (2013.01); A61L 27/427 (2013.01); A61L 2430/02 (2013.01); A61L 2430/38 (2013.01)] | 7 Claims |
1. A precursor composition comprising a non-aqueous slurry comprising a mixture of:
a solid phase comprising a mixture of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA), and
a non-aqueous liquid phase comprising a polymer and a non-aqueous solvent in which the polymer is soluble,
wherein
i) the non-aqueous solvent is selected from the group consisting of ethanol and tetrahydrofuran,
ii) optionally the liquid phase further comprises at least one additional non-aqueous solvent selected from the group consisting of acetic acid, acetone, methanol, 2-propanol, butanol, 2-butoxyethanol, benzyl alcohol, 1-methoxy-2-propanol, butyl glycol, n-butyl acetate, N,N-dimethylacetamide, N,N-dimethylformamide, dimethylsulfoxide, N-methyl-2-pyrrolidone (NMP), carbon tetrachloride, benzene, toluene, cyclohexanone, 2-nitropropane, 2-butanone, acetonitrile, dichloromethane, chloroform, and ethyl acetate, and
iii) the polymer is selected from the group consisting of poly(ethylene glycol), polyvinyl pyrrolidone (PVP), poly(methyl methacrylate) (PMMA), polyoxazoline, polyphosphoesters (PPE), dextran, polyvinyl butyral (PVB), polycaprolactone (PCL), and poly lactic-co-glycolic acid (PLGA).
|