US 11,684,681 B2
Method of detecting eosinophil degranulation in the respiratory tract
Leonard F. Pease, Salt Lake City, UT (US); Hedieh Saffari, Salt Lake City, UT (US); Gerald J. Gleich, Salt Lake City, UT (US); Kristin M. Leiferman, Salt Lake City, UT (US); Kathryn A. Peterson, Salt Lake City, UT (US); and Russell Morris Condie, Salt Lake City, UT (US)
Assigned to UNIVERSITY OF UTAH RESEARCH FOUNDATION, Salt Lake City, UT (US)
Filed by University of Utah Research Foundation, Salt Lake City, UT (US)
Filed on Jul. 19, 2021, as Appl. No. 17/379,402.
Application 17/379,402 is a continuation of application No. 16/502,328, filed on Jul. 3, 2019, granted, now 11,065,351.
Application 16/502,328 is a continuation of application No. 15/719,827, filed on Sep. 29, 2017, granted, now 10,376,602, issued on Aug. 13, 2019.
Application 15/719,827 is a continuation of application No. 14/402,070, granted, now 9,789,212, issued on Oct. 17, 2017, previously published as PCT/US2013/041595, filed on May 17, 2013.
Claims priority of provisional application 61/786,909, filed on Mar. 15, 2013.
Claims priority of provisional application 61/688,650, filed on May 18, 2012.
Prior Publication US 2022/0054662 A1, Feb. 24, 2022
Int. Cl. A61K 51/04 (2006.01); A61K 51/08 (2006.01)
CPC A61K 51/0491 (2013.01) [A61K 51/08 (2013.01)] 12 Claims
 
1. A method of detecting eosinophil degranulation in a respiratory tract passage of a subject, the method comprising:
administering radiolabeled heparin to the respiratory tract passage of the subject, wherein the radiolabeled heparin binds to one or more eosinophil granule proteins in the mucosal tissue of the respiratory tract passage; and
detecting the radiolabeled heparin in the mucosal tissue of the respiratory tract passage by one of single-photon emission computed tomography (SPECT), positron emission tomography (PET), conventional or computed tomography (CT), magnetic resonance imaging (MRI), or combinations thereof, hereby wherein detecting the radiolabeled heparin in the mucosal tissue is indicative of eosinophil degranulation in the respiratory tract passage of the subject.