	US 11,684,653 B2
	Compositions and method for reducing virulence of microorganisms
Eugene Chang, Chicago, IL (US); and Jeannette Messer, Chicago, IL (US)
Assigned to THE CLEVELAND CLINIC FOUNDATION, Cleveland, OH (US)
Filed by The Cleveland Clinic Foundation, Cleveland, OH (US)
Filed on Mar. 3, 2020, as Appl. No. 16/807,792.
Claims priority of provisional application 62/821,854, filed on Mar. 21, 2019.
Claims priority of provisional application 62/814,599, filed on Mar. 6, 2019.
Prior Publication US 2020/0282017 A1, Sep. 10, 2020
Int. Cl. A61K 38/17 (2006.01); A61P 1/00 (2006.01); A61K 47/64 (2017.01); C12Q 1/02 (2006.01)

CPC A61K 38/1709 (2013.01) [A61K 47/64 (2017.08); A61P 1/00 (2018.01); C12Q 1/025 (2013.01)]

9 Claims

1. A method of treating or preventing microbial virulence in a subject suffering from decreased high mobility group box 1 (HMGB1) protein levels and/or a deficiency in HMGB1 function, the method comprising:

identifying decreased HMGB1 protein levels and/or a deficiency in HMGB1 function in the subject; and

administering a composition comprising an HMGB1 polypeptide or variant or fragment thereof and a pharmaceutically acceptable carrier to the subject, wherein said administering prevents or treats microbial virulence in said subject.