US 11,684,588 B2
Multilayer composite material
Giovanni Gennari, Abano Terme (IT); Monica Campisi, Abano Terme (IT); and Anna Maria Zanellato, Abano Terme (IT)
Assigned to FIDIA FARMACEUTICI S.P.A., Abano Terme (IT)
Appl. No. 16/975,672
Filed by FIDIA FARMACEUTICI S.P.A., Abano Terme (IT)
PCT Filed Feb. 26, 2019, PCT No. PCT/IB2019/051534
§ 371(c)(1), (2) Date Aug. 25, 2020,
PCT Pub. No. WO2019/162928, PCT Pub. Date Aug. 29, 2019.
Claims priority of application No. 102018000003034 (IT), filed on Feb. 26, 2018; and application No. 102018000021112 (IT), filed on Dec. 27, 2018.
Prior Publication US 2020/0405656 A1, Dec. 31, 2020
Int. Cl. A61K 9/70 (2006.01); A61F 13/00 (2006.01); A61K 33/38 (2006.01); A61K 38/39 (2006.01); A61K 47/26 (2006.01); A61K 47/34 (2017.01); A61K 47/36 (2006.01)
CPC A61K 9/7092 (2013.01) [A61F 13/00063 (2013.01); A61K 33/38 (2013.01); A61K 38/39 (2013.01); A61K 47/26 (2013.01); A61K 47/34 (2013.01); A61K 47/36 (2013.01)] 5 Claims
 
1. A dressing comprising:
a) a three-dimensional matrix comprising at least a first layer and a second layer of a fabric consisting of a polyethylene terephthalate (PET) fiber, wherein said first layer and said second layer are superimposed and welded together in at least two distinct and separate points, so as to define a space S between the first layer and the second layer; and
b) a composition consisting of hyaluronic acid and at least one excipient suitable for pharmaceutical use, wherein said composition b) is contained in at least a part of the space S between the first layer and the second layer;
wherein said dressing has dimensions of about 9×9 cm and contains 4.1±0.5 g of composition b) prepared starting from hyaluronic acid having a weight average molecular weight ranging from 150 to 250 kDa, wherein the total content of hyaluronic acid (HA) in the dressing is equal to 2 mg;
wherein said composition b) is present at least in part on the surfaces of the first layer and second layer that are external to the intermediate space S; and
wherein the fabric of the first layer and of the second layer is a monofilament fabric.