CPC A61J 1/1468 (2015.05) [A61J 1/00 (2013.01); A61J 1/035 (2013.01); A61J 1/05 (2013.01); A61L 31/04 (2013.01); A61L 31/08 (2013.01); A61L 31/088 (2013.01); A61L 31/143 (2013.01); A61L 31/16 (2013.01); A61M 5/3129 (2013.01); B65D 25/14 (2013.01); C23C 16/029 (2013.01); C23C 16/045 (2013.01); C23C 16/401 (2013.01); C23C 16/45523 (2013.01); C23C 16/50 (2013.01); G01N 27/227 (2013.01); G01N 33/5308 (2013.01); G01N 33/5438 (2013.01); G01N 33/74 (2013.01); A61L 2420/02 (2013.01); A61L 2420/08 (2013.01); A61M 2005/3131 (2013.01); A61M 2205/0238 (2013.01); G01N 2333/62 (2013.01); G01N 2800/042 (2013.01)] | 20 Claims |
1. A pharmaceutical package comprising:
a vessel having a lumen defined at least in part by a thermoplastic wall, the thermoplastic wall having an interior surface facing the lumen, an outer surface, and a coating set on the interior surface comprising:
a tie coating or layer comprising SiOxCy or SiNxCy wherein x is from about 0.5 to about 2.4 and y is from about 0.6 to about 3, the tie coating or layer having an interior surface facing the lumen and an outer surface facing the wall interior surface;
a barrier coating or layer having an interior surface facing the lumen and an outer surface facing the interior surface of the tie coating or layer, the barrier coating or layer being effective to reduce the ingress of atmospheric gas into the lumen compared to a vessel without a barrier coating or layer;
a pH protective coating or layer comprising SiOxCy or SiNxCy wherein x is from about 0.5 to about 2.4 and y is from about 0.6 to about 3, the pH protective coating or layer having an interior surface facing the lumen and an outer surface facing the interior surface of the barrier coating or layer; and
a fluid having a pH greater than 5 contained in the lumen;
wherein the pH protective coating or layer and tie coating or layer together are effective to keep the barrier coating or layer at least substantially undissolved as a result of attack by the fluid for a period of at least six months.
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