US 11,684,404 B2
Methods and devices for optoacoustic stimulation
Chen Yang, Newton, MA (US); Ji-Xin Cheng, Newton, MA (US); Nan Zheng, Allston, MA (US); Yueming Li, Brighton, MA (US); Ying Jiang, Brighton, MA (US); Lu Lan, Allston, MA (US); and Linli Shi, Allston, MA (US)
Assigned to Trustees of Boston University, Boston, MA (US)
Filed by Trustees of Boston University, Boston, MA (US)
Filed on Mar. 9, 2022, as Appl. No. 17/690,948.
Claims priority of provisional application 63/177,029, filed on Apr. 20, 2021.
Claims priority of provisional application 63/158,566, filed on Mar. 9, 2021.
Prior Publication US 2022/0287758 A1, Sep. 15, 2022
Int. Cl. A61B 18/04 (2006.01); B01J 19/10 (2006.01); B82Y 40/00 (2011.01); B82Y 30/00 (2011.01); A61B 5/00 (2006.01); A61B 18/26 (2006.01); A61B 8/00 (2006.01); A61B 18/22 (2006.01); G01N 29/24 (2006.01); G01S 15/89 (2006.01); F21V 8/00 (2006.01); G02B 6/02 (2006.01); G02B 6/34 (2006.01)
CPC A61B 18/04 (2013.01) [A61B 5/0095 (2013.01); A61B 18/26 (2013.01); B01J 19/10 (2013.01); B82Y 30/00 (2013.01); B82Y 40/00 (2013.01); A61B 5/0035 (2013.01); A61B 5/0059 (2013.01); A61B 8/4416 (2013.01); A61B 8/4483 (2013.01); A61B 2018/2205 (2013.01); A61B 2018/2244 (2013.01); A61B 2018/2261 (2013.01); A61B 2018/266 (2013.01); G01N 29/2431 (2013.01); G01S 15/8968 (2013.01); G02B 6/004 (2013.01); G02B 6/021 (2013.01); G02B 6/02033 (2013.01); G02B 6/02104 (2013.01); G02B 6/34 (2013.01)] 23 Claims
OG exemplary drawing
 
1. A tapered fiber optoacoustic emitter (TFOE) comprising:
a nanosecond laser configured to emit laser pulses; and
an optic fiber with a tip, the optic fiber configured to guide the laser pulses, the tip having a coating including a diffusion layer and a thermal expansion layer,
wherein:
the diffusion layer comprises epoxy and zinc oxide nanoparticles configured to diffuse the light while restricting localized heating around the diffusion layer;
the thermal expansion layer comprises carbon nanotubes (CNTs) and Polydimethylsiloxane (PDMS) configured to convert the laser pulses to generate ultrasound; and
a frequency of the ultrasound is determined based on a thickness of the diffusion layer and a CNT concentration of the thermal expansion layer.