US 11,684,274 B2
Method and apparatus for cuff-less blood pressure measurement in a mobile device
Ramakrishna Mukkamala, East Lansing, MI (US); Anand Chandrasekhar, East Lansing, MI (US); and Jin-Oh Hahn, Rockville, MD (US)
Assigned to Board of Trustees of Michigan State University, East Lansing, MI (US)
Filed by Board of Trustees of Michigan State University, East Lansing, MI (US); and University of Maryland, College Park, MD (US)
Filed on Jun. 2, 2021, as Appl. No. 17/336,739.
Application 17/336,739 is a division of application No. 16/515,590, filed on Jul. 18, 2019, granted, now 11,179,047.
Application 16/515,590 is a continuation of application No. 16/118,530, filed on Aug. 31, 2018, granted, now 10,398,324, issued on Sep. 3, 2019.
Application 16/118,530 is a continuation in part of application No. PCT/US2017/020739, filed on Mar. 3, 2017.
Claims priority of provisional application 62/555,028, filed on Sep. 6, 2017.
Claims priority of provisional application 62/554,795, filed on Sep. 6, 2017.
Claims priority of provisional application 62/436,477, filed on Dec. 20, 2016.
Claims priority of provisional application 62/303,074, filed on Mar. 3, 2016.
Prior Publication US 2021/0298618 A1, Sep. 30, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/00 (2006.01); A61B 5/021 (2006.01); A61B 5/026 (2006.01); A61B 5/0205 (2006.01); A61B 5/0295 (2006.01); A61B 5/022 (2006.01); A61B 5/024 (2006.01)
CPC A61B 5/02141 (2013.01) [A61B 5/0261 (2013.01); A61B 5/0295 (2013.01); A61B 5/02225 (2013.01); A61B 5/02416 (2013.01); A61B 5/6898 (2013.01); A61B 5/706 (2013.01); A61B 5/743 (2013.01); A61B 5/0077 (2013.01); A61B 5/02055 (2013.01); A61B 2560/0462 (2013.01); A61B 2562/0238 (2013.01); A61B 2562/0247 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A mobile device, comprising:
a housing defining two opposing exterior surfaces, each of the opposing exterior surfaces being substantially planar;
a processor enclosed within the housing;
a display unit integrated into a first of the two opposing exterior surfaces;
a sensing unit integrated into the housing, wherein the sensing unit includes a reflectance-mode photoplethysmography (PPG) sensor configured to measure blood volume oscillations, and a force sensor disposed underneath the PPG sensor and configured to measure applied pressure;
a visual guide disposed on an exterior surface of the housing adjacent to the sensing unit, such that the visual guide is an indicia for placement of the fingertip on the device; and
a non-transitory computer-readable medium enclosed in the housing that stores instructions that, when executed by the processor, cause the processor to:
measure pressure applied to the sensing unit by a fingertip of a user,
measure blood volume oscillations in the fingertip,
guide the user via the display unit to vary pressure being applied to the sensing unit while the blood volume oscillations and pressure are measured,
generate an oscillogram from the measured pressure and the measured blood volume oscillations, where the oscillogram plots amplitude of blood volume oscillations as a function of the measured pressure,
calculate a blood pressure value from the oscillogram, and
present the blood pressure value on the display unit.