	US 11,680,105 B2
	Antibody fragments for detecting cancer and methods of use
Jayanth Panyam, Minneapolis, MN (US); Stephen Kalscheuer, Minneapolis, MN (US); and Vidhi D. Khanna, Minneapolis, MN (US)
Assigned to REGENTS OF THE UNIVERSITY OF MINNESOTA, Minneapolis, MN (US)
Filed by REGENTS OF THE UNIVERSITY OF MINNESOTA, Minneapolis, MN (US)
Filed on Jan. 16, 2020, as Appl. No. 16/745,153.
Claims priority of provisional application 62/793,726, filed on Jan. 17, 2019.
Prior Publication US 2020/0332020 A1, Oct. 22, 2020
Int. Cl. A61K 47/68 (2017.01); A61P 35/00 (2006.01); A61K 39/00 (2006.01); C07K 16/30 (2006.01)

CPC C07K 16/3015 (2013.01) [A61K 47/6803 (2017.08); A61K 47/6855 (2017.08); A61P 35/00 (2018.01); A61K 2039/505 (2013.01); C07K 2317/56 (2013.01); C07K 2317/622 (2013.01); C07K 2319/00 (2013.01)]

19 Claims

1. An isolated antibody Tw1S4_AM6 or fragment thereof, comprising at least one heavy chain variable region and at least one light chain variable region, wherein the heavy chain variable region comprises heavy chain complementarity-determining regions comprising each of amino acid sequences SEQ ID NOs: 2, 3 and 4, and wherein the light chain variable region comprises light chain complementarity-determining regions comprising each of amino acid sequences SEQ ID NOs: 5, 6 and 7.