CPC C07C 50/28 (2013.01) [A61P 39/06 (2018.01); C07C 50/24 (2013.01); C07C 225/24 (2013.01); C07C 317/04 (2013.01); C07D 207/06 (2013.01); C07D 213/65 (2013.01); C07D 295/108 (2013.01)] | 18 Claims |
1. A compound of the formula I:
or the hydroquinone form thereof;
wherein:
R1 and R2 are independently C1-C10 alkyl;
R3 is C1-C6 alkyl or —NHS(O)2CH3;
R4 is C8-C12 n-alkyl and R5 is C1 haloalkyl, —O—C1-C6 alkyl, —O—C1-C6 haloalkyl, —O-phenyl, —O-heteroaryl, or —NR6R7, wherein R5 is attached to R4 at any chemically possible location on the C8-C12 n-alkyl group; or
R4 is C8-C12 alkyl and R5 is C1 haloalkyl, —O—C2-C6 alkyl, —O—C3-C6 haloalkyl, —O-phenyl, —O-heteroaryl, or —NR6R7, wherein R5 is attached to R4 at any chemically possible location on the C8-C12 alkyl group;
R6 and R7 are independently selected from the group consisting of H and C1-C6 alkyl; or R6 and R7 together with the nitrogen atom to which they are attached form a 3-7 membered saturated heterocyclic ring; and
phenyl and heteroaryl are optionally independently substituted with 1-4 substituents each independently selected from the group consisting of C1-C4 alkyl; or a salt, a stereoisomer, or mixture of stereoisomers thereof;
wherein:
when R4 is C8 n-alkyl, then R5 is not CF3;
when R4 is C9 n-alkyl, then R5 is not —CH2Br; and
when R4 is C10 n-alkyl, then R5 is not —OCH3 or —OCH2CF3.
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