US 11,679,349 B2
Single pass tangential flow filtration systems and tangential flow filtration systems with recirculation of retentate
Jonathan Steen, Worcester, MA (US); Mikhail Kozlov, Lexington, MA (US); Herbert Lutz, Playa del Ray, CA (US); Joseph Parrella, Westford, MA (US); Elizabeth M. Goodrich, Bedford, MA (US); and Bala Raghunath, Bangalore (IN)
Assigned to EMD Millipore Corporation, Burlington, MA (US)
Filed by EMD Millipore Corporation, Burlington, MA (US)
Filed on May 10, 2021, as Appl. No. 17/315,721.
Application 16/208,018 is a division of application No. 14/839,779, filed on Aug. 28, 2015, granted, now 10,195,550, issued on Feb. 5, 2019.
Application 17/315,721 is a continuation of application No. 16/208,018, filed on Dec. 3, 2018, granted, now 11,033,839.
Claims priority of provisional application 62/043,811, filed on Aug. 29, 2014.
Prior Publication US 2021/0260504 A1, Aug. 26, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. B01D 29/90 (2006.01); B01D 61/14 (2006.01); B01D 63/08 (2006.01); B01D 29/52 (2006.01); B01D 29/60 (2006.01)
CPC B01D 29/908 (2013.01) [B01D 29/52 (2013.01); B01D 29/603 (2013.01); B01D 61/145 (2013.01); B01D 61/146 (2022.08); B01D 61/147 (2013.01); B01D 63/082 (2013.01); B01D 2313/105 (2013.01); B01D 2313/125 (2013.01); B01D 2313/21 (2013.01); B01D 2315/10 (2013.01); B01D 2315/16 (2013.01); B01D 2319/022 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A method of filtering a liquid feed, comprising:
a) passing a liquid feed through a tangential flow filtration (TFF) system that comprises:
a plurality of stacked filtration modules that are fluidly connected, each filtration module comprising:
a single manifold segment comprising a first manifold for receiving and carrying the feed into the filtration module, a second manifold for receiving and carrying retentate out of the filtration module, and a third manifold for receiving and carrying permeate through the filtration module; and
a plurality of TFF cassettes that are stacked on one or both faces of, and are fluidly connected to, the manifold segment, wherein the manifold segments are stacked and the manifolds in the manifold segments are coupled to create a centralized serial flow path through the system for feed and retentate;
a feed inlet on the first filtration module in the system;
a retentate outlet on the last filtration module in the system;
the TFF system having a liquid flow path that is parallel through the cassettes in each filtration module and serial through the manifold segments in adjacent filtration modules by coupling the first manifold in each manifold segment to the second manifold of an adjacent manifold segment, such that the retentate of one module serves as the feed for the manifold segment of the next filtration module, except that the first manifold in the first manifold segment of the filtration module in the system is connected to the feed inlet and the second manifold in the manifold segment of the last filtration module in the system is connected to the retentate outlet and wherein diverter plates are explicitly excluded;
b) recovering permeate in a permeate container and recovering a portion of the retentate from the system in a retentate container without recirculation of the recovered retentate through the TFF system.