US 11,679,140 B2
Prevention and/or treatment of hearing loss or impairment
Christine Petit, Paris (FR); Paul Avan, Clermont-Ferrand (FR); Sedigheh Delmaghani, Paris (FR); Jean Defourny, Paris (FR); Asadollah Aghaie, Paris (FR); Saaid Safieddine, Paris (FR); and Alice Emptoz, Paris (FR)
Assigned to INSTITUT PASTEUR, Paris (FR); Centre National de la Recherche Scientifique (CNRS), Paris (FR); Universite Clermont Auvergne, Clermont-Ferrand (FR); and Sorbonne Universite, Paris (FR)
Filed by INSTITUT PASTEUR, Paris (FR); Centre National de la Recherche Scientifique (CNRS), Paris (FR); Sorbonne Université, Paris (FR); and Université Clermont Auvergne, Clermont-Ferrand (FR)
Filed on Jul. 27, 2020, as Appl. No. 16/940,010.
Application 16/940,010 is a continuation of application No. 15/551,096, granted, now 10,751,385, previously published as PCT/EP2016/053613, filed on Feb. 19, 2016.
Claims priority of application No. 15305270 (EP), filed on Feb. 20, 2015; and application No. 15306664 (EP), filed on Oct. 16, 2015.
Prior Publication US 2020/0353039 A1, Nov. 12, 2020
Int. Cl. A61K 38/17 (2006.01); A61K 8/64 (2006.01); A61K 35/761 (2015.01); C12N 15/86 (2006.01); C12N 7/00 (2006.01); A61K 9/00 (2006.01); A61Q 19/02 (2006.01); A61Q 19/08 (2006.01); A61K 48/00 (2006.01); C12N 15/113 (2010.01)
CPC A61K 38/1709 (2013.01) [A61K 8/64 (2013.01); A61K 9/0019 (2013.01); A61K 9/0046 (2013.01); A61K 35/761 (2013.01); A61K 38/17 (2013.01); A61K 48/00 (2013.01); A61K 48/005 (2013.01); A61K 48/0075 (2013.01); A61Q 19/02 (2013.01); A61Q 19/08 (2013.01); C12N 7/00 (2013.01); C12N 15/113 (2013.01); C12N 15/86 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0306 (2013.01); A61K 2800/91 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2710/10021 (2013.01); C12N 2710/10043 (2013.01); C12N 2750/14143 (2013.01)] 17 Claims
 
1. A method of gene therapy for Usher syndrome, comprising administering an effective amount of a vector comprising a coding sequence for an USH1 gene product, which is the SANS gene product, to a subject in need thereof.