US 11,678,967 B2
Intravascular cell therapy device
Noel Caplice, Mallow (IE)
Assigned to Provasctec Limited, Galway (IE)
Appl. No. 16/489,601
Filed by University College Cork—National University of Ireland, Cork, Mallow (IE)
PCT Filed Feb. 28, 2018, PCT No. PCT/EP2018/054922
§ 371(c)(1), (2) Date Aug. 28, 2019,
PCT Pub. No. WO2018/158311, PCT Pub. Date Sep. 7, 2018.
Claims priority of application No. 17158548 (EP), filed on Feb. 28, 2017.
Prior Publication US 2020/0015953 A1, Jan. 16, 2020
Int. Cl. A61F 2/06 (2013.01); A61L 27/54 (2006.01); A61F 2/02 (2006.01); A61L 27/44 (2006.01); A61L 27/50 (2006.01); A61L 27/58 (2006.01); A61F 2/848 (2013.01)
CPC A61F 2/022 (2013.01) [A61F 2/06 (2013.01); A61L 27/44 (2013.01); A61L 27/507 (2013.01); A61L 27/54 (2013.01); A61L 27/58 (2013.01); A61F 2002/8486 (2013.01); A61F 2210/0004 (2013.01); A61F 2230/0023 (2013.01); A61F 2230/0067 (2013.01); A61F 2230/0069 (2013.01); A61F 2250/0067 (2013.01); A61L 2300/64 (2013.01)] 23 Claims
OG exemplary drawing
 
1. An intravascular cell therapy device comprising a scaffold that is radially adjustable between a contracted orientation suitable for transluminal delivery to a vascular locus and an expanded orientation suitable for embedding in a vascular wall, in which the scaffold comprises a plurality of sidewall panels arranged around a longitudinal axis of the scaffold, and adjustable couplings between the sidewall panels configured for adjustment of the scaffold between the expanded orientation and the contracted orientation, in which each sidewall panel includes a porous matrix formed by electrospinning and configured for being seeded with cells, retaining the cells after implantation in a vascular environment, and degrading in a vascular environment, and live proangiogenic cells loaded into the porous matrix, in which the porous matrix has an average pore size of 30 to 100 microns, and in which the porous matrix is suitable for releasing proangiogenic factors secreted by the live proangiogenic cells into the vascular environment, wherein the adjustable couplings between the sidewall panels are adjustable between an inwardly folded configuration when the scaffold is in the contracted orientation and an unfolded extended configuration when the scaffold is in the expanded orientation, wherein in the inwardly folded configuration the adjustable couplings extend inward from the sidewall panels.