US 11,674,921 B2
Online reference calibration
Steven A. Gahlings, Cambridge (GB); Nathan Lawrence, Hail Weston (GB); and Kay Louise McGuinness, Harston (GB)
Assigned to ANB Sensors Ltd, Cambridgeshire (GB)
Appl. No. 16/755,516
Filed by ANB Sensors Ltd, Cambridge (GB)
PCT Filed Oct. 11, 2018, PCT No. PCT/EP2018/077797
§ 371(c)(1), (2) Date Apr. 10, 2020,
PCT Pub. No. WO2019/073002, PCT Pub. Date Apr. 18, 2019.
Claims priority of application No. 1716652 (GB), filed on Oct. 11, 2017; application No. 1716660 (GB), filed on Oct. 11, 2017; and application No. PCT/EP2018/000097 (WO), filed on Feb. 12, 2018.
Prior Publication US 2020/0264131 A1, Aug. 20, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 27/416 (2006.01); G01N 27/30 (2006.01); G01N 27/333 (2006.01); G01N 27/36 (2006.01); G01N 27/403 (2006.01); G01N 27/48 (2006.01); G01N 33/18 (2006.01)
CPC G01N 27/301 (2013.01) [G01N 27/302 (2013.01); G01N 27/308 (2013.01); G01N 27/333 (2013.01); G01N 27/36 (2013.01); G01N 27/4035 (2013.01); G01N 27/4163 (2013.01); G01N 27/4165 (2013.01); G01N 27/4167 (2013.01); G01N 27/48 (2013.01); G01N 33/18 (2013.01)] 43 Claims
OG exemplary drawing
 
1. An online calibration system for an electrochemical sensor, comprising:
a calibration electrode in a reference solution, the calibration electrode comprising:
a redox species, wherein:
the redox species is configured to set a pH of the reference solution in a local environment proximal to the calibration electrode;
the redox species is configured to undergo oxidation and/or reduction when an electrochemical signal is applied to the calibration electrode; and
the redox species is sensitive to pH and generates a response to the applied electrochemical signal that is dependent on the pH of the local environment proximal to the calibration electrode, and
a polymeric layer positioned between the redox species and the reference solution.