| CPC G01N 21/65 (2013.01) [A61B 5/0075 (2013.01); A61B 5/14525 (2013.01); A61B 5/6866 (2013.01); A61M 1/14 (2013.01); A61M 1/1609 (2014.02); A61M 1/1619 (2014.02); A61M 1/1692 (2013.01); A61M 1/282 (2014.02); A61M 1/3609 (2014.02); G01N 33/492 (2013.01); G16H 10/40 (2018.01); G16H 20/40 (2018.01); A61M 2205/3313 (2013.01); A61M 2205/50 (2013.01); A61M 2205/52 (2013.01); G01N 21/658 (2013.01); G01N 2570/00 (2013.01)] | 5 Claims |
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1. A method comprising:
obtaining multiple dialysate or urine samples from a dialysis patient;
providing a Raman spectrum from each of the multiple samples of the patient;
providing one or more reference Raman spectrum;
detecting a molecular fingerprint of four or more analytes relative to one another in each of the Raman spectra, wherein four or more of the analytes are chosen from creatinine, uric acid, uric acid based compounds, interleukin-8, bilirubin, a1-anti-trypsin, arginine, homoarginine, urea, urea-based compounds, urea nitrogen based compounds, ammonium-based compounds, nitrogen-based compounds, vitamins, vitamin C, vitamin B12, folic acid, zinc, amino acids, proteins, nucleic acids, pharmaceutical compounds, 2-heptanal, 2-hexenal, 2-nonenal, 4-decenal, 4-HO-decenal, 4-HO-hexenal, 4-HO-nonenal, 4-HO-octenal, 4-pyrididone-3-carboxy-1-β-D-ribonucleoside, 8-Hydroxy-2’deoxyguanosine, α-Keto-δ-guanidinovlaeric acid, antranilic acid, argininic acid, dimethylarginine, cysteine, decanal, dimethylamine, ethylamine, guanidine, guanidinoacetic acid, guanidine succinic acid, hepatanal, hexanal, hypoxanthine, malondialdehyde, methylguanidine, monomethylamine, neopterine, nicotinamide, N-methyl-2-pyridone-5-carboxamide, N-methyl-4-pyridone-3-carboxamide, nonanal, noradrenaline, oxalate, phenylacetic acid, dimethylarginine, trimethylamine, trimethylamine-N-oxide, 3-carboxy-4-methyl-5-propyl-2-furan-propanoic acid, acrolein, carboxymethyllysine, dihydroxyphenylalanine, hippuric acid, homocysteine, indicant, indole-3-acetic acid, indoxyl sulfate, indoxyl-β-D-glucoronide, kynurenic acid, p-cresyl sulfate, pentosidine, phenol, putrescine, permidine, thiocyanate, α1-acid glycoprotein, α1-microglobulin, β-trace protein, β2-microglobulin, adiponectin, angiogenin, calcitonin, complement factor D, cystatin C, fibroblast growth factor-23, glutathione, reduced glutathione, insulin-like growth factor 1 (IGF-1), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10), leptin, hemoglobin, myoglobin, osteocalcin, parathyroid hormone (PTH), prolactin, resistin, retinal binding protein, soluble intracellular adhesion molecule-1, TNF-α, and vascular endothelial growth factor;
treating the patient according to a dialysis prescription; and
modifying the dialysis prescription to provide a dynamic dialysis prescription based on analyte kinetics of the four or more analytes relative to one another represented from the multiple samples of the patient and the reference, wherein the modifying comprises one or more of:
increasing or decreasing dialysis treatment time;
increasing or decreasing the rate of blood flow through a dialyzer; or
increasing or decreasing the frequency of dialysis treatments.
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