	US 11,674,901 B2
	Resonator networks for improved label detection, computation, analyte sensing, and tunable random number generation
Craig Laboda, Durham, NC (US); Chris Dwyer, Durham, NC (US); and Alvin R. Lebeck, Durham, NC (US)
Assigned to DUKE UNIVERSITY, Durham, NC (US)
Appl. No. 16/605,555
Filed by Duke University, Durham, NC (US)
PCT Filed Jun. 12, 2018, PCT No. PCT/US2018/037076 § 371(c)(1), (2) Date Oct. 16, 2019, PCT Pub. No. WO2018/231805, PCT Pub. Date Dec. 20, 2018.
Claims priority of provisional application 62/551,616, filed on Aug. 29, 2017.
Claims priority of provisional application 62/527,451, filed on Jun. 30, 2017.
Claims priority of provisional application 62/521,192, filed on Jun. 16, 2017.
Prior Publication US 2020/0124532 A1, Apr. 23, 2020
Int. Cl. G01N 21/64 (2006.01)

CPC G01N 21/6428 (2013.01) [G01N 21/6408 (2013.01); G01N 2021/6439 (2013.01)]

15 Claims

1. A label comprising:

two or more input resonators, wherein the input resonators comprise at least one of a fluorophore, a quantum dot, or a dye and all of the input resonators comprise the same fluorophore, quantum dot, or dye excited at a single wavelength;

an output resonator, wherein the output resonator comprises at least one of a fluorophore, a quantum dot, or a dye;

a receptor, wherein the receptor is an antibody, aptamer, or protein; and

an organic backbone,

wherein the receptor selectively interacts with an analyte of interest to permit detection of the presence, amount, or location of the analyte of interest in a sample,

wherein the two or more input resonators, the output resonator, and the receptor are coupled to the backbone, and

wherein the backbone maintains relative locations of the input resonators and the output resonator such that energy can be transmitted from each of the input resonators directly to the output resonator.