US 11,674,869 B2
Devices and methods for sample analysis with serial dilution
Wendian Shi, Irvine, CA (US); Yuan Gao, Irvine, CA (US); and Yuzhe Ding, Irvine, CA (US)
Assigned to CYTOCHIP, INC., Irvine, CA (US)
Appl. No. 16/971,623
Filed by CYTOCHIP, INC., Irvine, CA (US)
PCT Filed Feb. 26, 2019, PCT No. PCT/US2019/019555
§ 371(c)(1), (2) Date Aug. 20, 2020,
PCT Pub. No. WO2019/168835, PCT Pub. Date Sep. 6, 2019.
Claims priority of provisional application 62/635,996, filed on Feb. 27, 2018.
Prior Publication US 2020/0400534 A1, Dec. 24, 2020
Int. Cl. G01N 1/20 (2006.01); G01N 1/38 (2006.01)
CPC G01N 1/2035 (2013.01) [G01N 1/38 (2013.01); G01N 2001/2057 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A device comprising a fluidic cartridge, wherein the fluidic cartridge comprises:
a first chamber for receiving a sample and a first reagent to form a sample mixture 1;
a metering chamber for metering a first portion of the sample mixture 1, the metering chamber being connected to the first chamber; and
a reader instrument for receiving the device and performing a sample analysis,
wherein:
the reader instrument is configured to apply a driving mechanism to the fluidic cartridge to meter the first portion of the sample mixture 1 in the metering chamber;
the driving mechanism is configured to drive the sample mixture 1 to contact a hydrophilic surface in the metering chamber, the hydrophilic surface being a part of a surface of the metering chamber; and
the driving mechanism is configured to be stopped upon the sample mixture 1 contacting the hydrophilic surface.