| CPC C11B 9/00 (2013.01) [A61K 8/068 (2013.01); A61K 9/1075 (2013.01)] | 4 Claims |
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1. A process for producing a microemulsion system of nano essential oil comprising the steps of:
(i) preparing a dispersed phase by heating an essential oil to a temperature between 60 and 100° C., the essential oil selected from a group consisting of: Basil; Rose; Amber; Bergamot; Rosemary; Black tea; Black pepper; Tea tree; Tabac; Cedarwood; Thyme; Fig leaf; Clove; Ylang Ylang; Ambroxan; Frankincense; Grapefruit; Daisy; Geranium; Vetiver; Saffron; Lavender; Sandalwood; Oud; Nutmeg; Musk; Whisky wine; Palmarosa; Jasmine; Rum; Patchouli; Magnolia flower; and Cinnamon;
(ii) preparing a carrier by heating a mixture of diethylene glycol monoethyl ether and lecithin at a weight ratio of between 5:1.5 and 6:1 to a temperature ranging from 60° C. to 100° C. under vacuum by using a rotary vacuum evaporator system, followed by cooling the mixture to 30° C., then ultrasonicating the mixture for 30 minutes, followed by magnetic stirring, and then heating the mixture at a temperature from 60° C. to 100° C., within 30 minutes, collecting the mixture and introducing into the rotary vacuum evaporator system, and continuing to stir at 100° C.;
(iii) adding the carrier to the dispersed phase obtained in step (i) at a weight ratio of between 2:1.5 and 2:1 while keeping a dispersed phase temperature between 60° C. and 100° C. after addition the carrier, while simultaneously stirring at a rate ranging from 400 to 800 rpm under vacuum; then passing the mixture through a system of a high-pressure homogeneous machine integrated with a dispersion nozzle;
(iv) adding the mixture obtained in step (iii) to Capryol 90 (propylene glycol monocaprylate) at a weight ratio of between 4:1.5 and 4.5:1 while keeping the mixture temperature between 60° C. and 100° C. after the addition of Capryol 90, then stirring at a rate ranging from 400 to 800 rpm under vacuum; and
(v) preparing a microemulsion system of nano essential oil by cooling the mixture obtained in step (iv) to 25° C., homogenizing the mixture by ultrasonication using an ultrasonic homogenizer over a period from 30 to 60 minutes to achieve a droplet size smaller than 100 nm, controlling a quality of a resultant product by dissolution in water and performing emulsifying on the mixture in an emulsifying device at a stirring rate ranging from 400 to 800 rpm to obtain a microemulsion system of nano essential oil.
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