CPC C07K 14/5428 (2013.01) [A61K 38/2066 (2013.01); A61K 47/68 (2017.08); A61K 47/6889 (2017.08); A61P 35/00 (2018.01); C07K 1/22 (2013.01); C07K 16/42 (2013.01); A61K 38/00 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/53 (2013.01); C07K 2319/30 (2013.01)] | 24 Claims |
1. A method of treating a solid tumor resistant to treatment with an anti-PD1 antibody, the method comprising administering to a subject in need thereof an IL10 agonist comprising, from amino to carboxy terminus:
(a) an IgG Fc domain;
(b) a linker moiety; and
(c) an IL10 moiety.
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