US 11,673,928 B2
Genetically modified pig cells with an inactivated Etv2 gene
Daniel J. Garry, Eagan, MN (US); Mary G. Garry, Eagan, MN (US); Tara Rasmussen, Savage, MN (US); and Naoko Koyano, Shoreview, MN (US)
Assigned to Regents of the University of Minnesota, Minneapolis, MN (US)
Appl. No. 15/554,585
Filed by Regents of the University of Minnesota, Minneapolis, MN (US)
PCT Filed Mar. 3, 2016, PCT No. PCT/US2016/020768
§ 371(c)(1), (2) Date Aug. 30, 2017,
PCT Pub. No. WO2016/141234, PCT Pub. Date Sep. 9, 2016.
Claims priority of provisional application 62/127,330, filed on Mar. 3, 2015.
Prior Publication US 2018/0037620 A1, Feb. 8, 2018
Int. Cl. C12N 5/00 (2006.01); C07K 14/47 (2006.01); A01K 67/027 (2006.01); C12N 5/073 (2010.01); C12N 5/0735 (2010.01); C12N 15/877 (2010.01); C12N 15/09 (2006.01)
CPC C07K 14/4705 (2013.01) [A01K 67/0271 (2013.01); A01K 67/0276 (2013.01); C12N 5/0604 (2013.01); C12N 5/0606 (2013.01); C12N 15/09 (2013.01); C12N 15/8778 (2013.01); A01K 2207/15 (2013.01); A01K 2217/075 (2013.01); A01K 2227/108 (2013.01); A01K 2267/025 (2013.01)] 1 Claim
 
1. A genetically modified isolated Sus scrofa pig cell, morula or blastocyst whose genome comprises a homozygous deletion of an endogenous ETV2 gene, wherein the cell, morula or blastocyst lacks functional endogenous ETV2 protein.