	US 11,673,902 B2
	Isoindolinone and indazole compounds for the degradation of EGFR
Christopher G. Nasveschuk, Stoneham, MA (US); Martin Duplessis, Somerville, MA (US); Jae Young Ahn, Somerville, MA (US); Alexander W. Hird, Belmont, MA (US); Ryan E. Michael, Erie, CO (US); Kiel Lazarski, Boston, MA (US); Yanke Liang, Belmont, MA (US); Georg Jaeschke, Basel (CH); Antonio Ricci, Biel-Benken (CH); Annick Goergler, Colmar (FR); and Daniel Rueher, Raedersdorf (FR)
Assigned to C4 Therapeutics, Inc., Watertown, MA (US)
Filed by C4 Therapeutics, Inc., Watertown, MA (US)
Filed on Jun. 17, 2022, as Appl. No. 17/843,769.
Application 17/843,769 is a continuation of application No. PCT/US2020/066211, filed on Dec. 18, 2020.
Claims priority of provisional application 62/951,464, filed on Dec. 20, 2019.
Claims priority of provisional application 62/951,467, filed on Dec. 20, 2019.
Prior Publication US 2023/0110648 A1, Apr. 13, 2023
Int. Cl. C07D 519/00 (2006.01); A61K 47/32 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61K 9/02 (2006.01); A61K 9/08 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 9/00 (2006.01); A61K 47/26 (2006.01); A61K 47/38 (2006.01); C07D 487/04 (2006.01)

CPC C07D 519/00 (2013.01) [A61K 9/009 (2013.01); A61K 9/02 (2013.01); A61K 9/08 (2013.01); A61K 9/2013 (2013.01); A61K 9/2018 (2013.01); A61K 9/2054 (2013.01); A61K 9/485 (2013.01); A61K 9/4825 (2013.01); A61K 9/4858 (2013.01); A61K 9/4866 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/26 (2013.01); A61K 47/32 (2013.01); A61K 47/38 (2013.01); C07D 487/04 (2013.01)]

29 Claims

1. A compound of Formula:

or a pharmaceutically acceptable salt thereof;

wherein:

y is 0, 1, 2, or 3;

B* is heteroaryl or aryl optionally substituted with 1, 2, or 3 R³¹substituents;

R³¹is independently selected at each occurrence from the group consisting of hydrogen, F, Cl, Br, I, C_1-6-alkyl, cyano, C_1-6-alkoxy, halo-C_1-6-alkoxy, halo-C_1-6-alkyl, C_3-8-cycloalkyl, and halo-C_3-8-cycloalkyl and can be located on either ring where present on a bicycle;

R³²is hydrogen, F, Cl, Br, I, C_1-6-alkyl, halo-C_1-6-alkyl, C_3-8-cycloalkyl, or halo-C_3-8-cycloalkyl; and

R³³is hydrogen, F, Cl, Br, I, C_1-6-alkyl, halo-C_1-6-alkyl, C_3-8-cycloalkyl, or halo-C_3-8-cycloalkyl and can be located on the dihydropyrrole or imidazole ring.