CPC C07D 491/107 (2013.01) [C07D 401/04 (2013.01); C07D 401/14 (2013.01)] | 16 Claims |
1. A compound of Formula I-Y1:
or a pharmaceutically acceptable salt, solvate, hydrate, or stereoisomer thereof, wherein:
A is a 5- to 12-membered monocyclic or polycyclic aryl or heteroaryl;
Y1 is —S— or a direct bond;
Y2 is —NRa; wherein the bond on the left side of Y2, as drawn, is bound to the pyridine ring and the bond on the right side of the Y2 moiety, as drawn, is bound to R3;
R1 is independently, at each occurrence, —H, —C1-C6alkyl, —OH, halogen, or —NH2;
R2 is —OH or —C1-C6alkyl;
R3 is combined with Ra to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with one or more —C1-C6alkyl, —OH, —NH2, —CF3, —CHF2, or —CH2F;
R4 is —H, or —C1-C6alkyl, wherein each alkyl is optionally substituted with one or more —OH or halogen;
n is independently, at each occurrence, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
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