US 11,673,891 B2
Imidazopyrimidine compounds and uses thereof
Ofer Levy, Cambridge, MA (US); David J. Dowling, Brighton, MA (US); Francesco Borriello, Jamaica Plain, MA (US); David A. Scott, Newton, MA (US); Spencer E. Brightman, San Diego, CA (US); and Frederic Feru, Boston, MA (US)
Assigned to Dana-Farber Cancer Institute, Inc., Boston, MA (US); and Children's Medical Center Corporation, Boston, MA (US)
Appl. No. 16/764,171
Filed by Dana-Farber Cancer Institute, Inc., Boston, MA (US); and Children's Medical Center Corporation, Boston, MA (US)
PCT Filed Nov. 14, 2018, PCT No. PCT/US2018/061117
§ 371(c)(1), (2) Date May 14, 2020,
PCT Pub. No. WO2019/099564, PCT Pub. Date May 23, 2019.
Claims priority of provisional application 62/586,124, filed on Nov. 14, 2017.
Prior Publication US 2022/0242867 A1, Aug. 4, 2022
Int. Cl. C07D 487/04 (2006.01); A61K 31/4188 (2006.01); A61K 31/519 (2006.01); A61P 37/02 (2006.01); A61K 45/06 (2006.01)
CPC C07D 487/04 (2013.01) [A61K 31/519 (2013.01); A61K 45/06 (2013.01)] 19 Claims
 
1. A compound of Formula (I):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein:
R1A is substituted or unsubstituted phenyl or substituted or unsubstituted benzyl, or substituted or unsubstituted 6-membered heteroaryl;
R1 is halogen, substituted or unsubstituted C1-6 alkyl, —ORa, or —N(Ra1)2;
each instance of RA is halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORa, —N(Ra1)2, —SRa, —CN, —C(═O)Ra, —C(═O)ORa, —C(═O)N(Ra1)2, or —NO2;
each instance of RB is halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORa, —N(Ra1)2, —SRa, —CN, —C(═O)Ra, —C(═O)ORa, —C(═O)N(Ra1)2, or —NO2;
each instance of Ra is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom;
each instance of Ra1 is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, or two instances of Ra1 are joined to form a substituted or unsubstituted, heterocyclic ring, or substituted or unsubstituted, heteroaryl ring;
a is 1, 2, or 3; and
b is 0, 1, 2, or 3.