CPC C07D 403/04 (2013.01) [C07D 403/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01)] | 16 Claims |
1. A compound of Formula I:
or pharmaceutically acceptable salts, hydrates, solvates, stereoisomers, or tautomers thereof, wherein:
Z1 and Z3 are each independently N and Z2 is CR8;
R8 is H, (C1-C4) alkyl, (C1-C4) haloalkyl, or halogen;
R1 is H, (C1-C4) alkyl, (C1-C4) haloalkyl, —NH2, —NH(C1-C4) alkyl, —N((C1-C4) alkyl)2, or halogen;
R2 is H or (C1-C6) alkyl;
R3 is (C1-C4) alkoxy, (C1-C4) alkyl, (C1-C4) haloalkyl, or halogen;
R4 is —NR9R10 or a 5- to 7-membered heterocycle comprising 1-3 heteroatoms selected from N, O, and S and optionally substituted with one or more R11;
R9 is H or (C1-C4) alkyl;
R10 is (C1-C4) alkyl, (C1-C4) alkyl-NH(C1-C4) alkyl, or (C1-C4) alkyl-N((C1-C4) alkyl)2;
or R9 and R10 together with the nitrogen atom to which they are attached form a 5- to 7-membered heterocycle optionally comprising 1 or 2 additional heteroatoms selected from N, O, and S and optionally substituted with one or more R11;
each R11 is independently (C1-C4) alkyl, (C1-C4) haloalkyl, (C1-C4) alkoxy, or halogen;
R5 is —NR12C(O)R13 or —C(O)NR12R13;
R12 is H or (C1-C6) alkyl;
R13 is (C1-C6) alkyl or (C2-C6) alkenyl, wherein the alkyl or alkenyl is optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, and —NH2;
R6 and R7 together with the nitrogen atom to which they are attached form a substituent of the formula
wherein
X1, X2, X3, X4, X5 and X6 are each independently N, CH, or CR15; and
each R15 is independently (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) alkoxy, —OH, —NH2, —NH(C1-C6) alkyl, —N((C1-C6) alkyl)2, or halogen.
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