CPC C07C 231/12 (2013.01) [C07C 237/04 (2013.01); A61K 51/04 (2013.01); C07B 2200/05 (2013.01)] | 20 Claims |
1. A process of preparing a compound of Formula VIII:
or a salt thereof, comprising reacting a compound of Formula Ic:
with a compound of Formula IX:
in the presence of a base, wherein:
LG is a leaving group;
R1 is selected from the group consisting of H, C1-6 alkyl, and C1-6 haloalkyl;
each R3 is independently selected from the group consisting of halo, C1-6 alkyl, and C1-6 haloalkyl; and
n is an integer from 0 to 5.
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5. A process of preparing a compound of Formula X:
or a salt thereof, comprising reacting a compound of Formula Ic:
with a compound of Formula IXa:
wherein:
LG is a leaving group;
R1 is selected from the group consisting of H, C1-6 alkyl, and C1-6 haloalkyl;
each R3 is independently selected from the group consisting of halo, C1-6 alkyl, and C1-6 haloalkyl; and
n is an integer from 0 to 5.
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14. A process of preparing a compound of the following formula:
or a salt thereof, comprising reacting N-(2,6-dimethylphenyl)-2-(ethylamino)acetamide with 2-(fluoro-18F)ethyl 4-methylbenzenesulfonate, wherein the reacting is performed in a polar aprotic solvent.
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17. A process of preparing a compound of the following formula:
or a salt thereof, comprising reacting N-(2,6-dimethylphenyl)-2-(ethylamino)acetamide with 1-bromo-2-(fluoro-18F)ethane in the presence of NaI, wherein the reaction is performed in a polar aprotic solvent.
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18. A process of preparing a compound of the following formula:
or a salt thereof, comprising reacting N-(2,6-dimethylphenyl)-2-(ethylamino)acetamide with 1-(fluoro-18F)-2-iodoethane, wherein the reaction is performed in a polar aprotic solvent.
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