CPC A61K 51/1021 (2013.01) [A61K 51/1093 (2013.01); C07K 16/249 (2013.01)] | 11 Claims |
1. A method for in vivo immunoimaging interferon gamma (IFN-γ) as a marker of active T cells in a subject with cancer, comprising:
administering a labeled-antibody conjugate to a subject, wherein the labeled-antibody conjugate comprises:
an antibody that specifically binds to IFN-γ, and
a detection label conjugated to the antibody, wherein the detection label is a radionuclide tracer selected from 11C, 13N, 15O, 18F, 44Sc, 45Ti, 52Mn, 64Cu, 68Ga, 76Br, 82Rb, 86Y, 89Zr, 111In, 124I, 43K, 52Fe, 57Co, 67Cu, 67Ga, 77Br, 81Rb, 81mKr, 87mSr, 113mIn, 123I, 127Cs, 129Cs, 132I, 197Hg, 203Pb, 206Bi, or a combination of any two or more thereof; and
detecting the presence of the labeled-antibody conjugate in the subject in vivo by imaging, wherein specific binding of the labeled-antibody conjugate to IFN-γ indicates the presence of activated T cells.
|