US 11,672,876 B2
Imageable embolic microsphere
Matthew R. Dreher, West Conshohocken, PA (US); Bradford J. Wood, Bethesda, MD (US); Ayele H. Negussie, Bethesda, MD (US); Andrew Lennard Lewis, Surrey (GB); and Yiqing Tang, Surrey (GB)
Assigned to BIOCOMPATIBLES UK LIMITED, Farnham (GB); and THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, Bethesda, MD (US)
Filed by Biocompatibles UK Limited, Surrey (GB); and THE UNITED STATES OF AMERICA, as represented by the Secretary Department of Health and Human Service, Bethesda, MD (US)
Filed on Jan. 22, 2020, as Appl. No. 16/749,370.
Application 16/749,370 is a continuation of application No. 16/381,204, filed on Apr. 11, 2019, abandoned.
Application 16/381,204 is a continuation of application No. 14/777,168, granted, now 10,307,493, issued on Jun. 4, 2019, previously published as PCT/US2014/027395, filed on Mar. 14, 2014.
Claims priority of provisional application 61/790,373, filed on Mar. 15, 2013.
Prior Publication US 2020/0155711 A1, May 21, 2020
Int. Cl. A61K 9/00 (2006.01); A61K 49/04 (2006.01); C08F 116/06 (2006.01); C08L 29/04 (2006.01); B82Y 5/00 (2011.01)
CPC A61K 49/0442 (2013.01) [A61K 49/0438 (2013.01); A61K 49/0476 (2013.01); A61K 49/0485 (2013.01); C08F 116/06 (2013.01); C08L 29/04 (2013.01); B82Y 5/00 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method of making a radiopaque hydrogel bead, comprising:
forming an activated hydrogel bead by reacting a preformed hydrogel bead with a carbonyldiimidazole or a carbodiimide; and
reacting functional groups on the activated hydrogel bead with an iodinated compound such at the iodinated compound is covalently coupled to the activated hydrogel bead, wherein the iodinated compound is an aromatic iodine containing compound.