	US 11,672,870 B2
	Transduction
James Dixon, Nottinghamshire (GB); Kevin Shakesheff, Nottinghamshire (GB); and Chris Denning, Nottinghamshire (GB)
Assigned to UNIVERSITY OF NOTTINGHAM, Nottinghamshire (GB)
Filed by The University of Nottingham, Nottinghamshire (GB)
Filed on Feb. 4, 2019, as Appl. No. 16/266,535.
Application 16/266,535 is a continuation of application No. 15/105,030, granted, now 10,226,537, previously published as PCT/GB2014/053764, filed on Dec. 18, 2014.
Claims priority of application No. 1322396 (GB), filed on Dec. 18, 2013.
Prior Publication US 2019/0216941 A1, Jul. 18, 2019
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/726 (2006.01); A61K 31/727 (2006.01); A61K 38/17 (2006.01); A61K 39/395 (2006.01); A61K 47/64 (2017.01); C07K 14/705 (2006.01); C07K 16/18 (2006.01); C07K 19/00 (2006.01); C12N 15/63 (2006.01); C07K 14/475 (2006.01); A61K 39/00 (2006.01)

CPC A61K 47/645 (2017.08) [A61K 31/726 (2013.01); A61K 31/727 (2013.01); A61K 38/177 (2013.01); A61K 39/3955 (2013.01); C07K 14/475 (2013.01); C07K 14/705 (2013.01); C07K 16/18 (2013.01); C07K 19/00 (2013.01); C12N 15/63 (2013.01); A61K 2039/505 (2013.01); C07K 2319/01 (2013.01); C07K 2319/10 (2013.01); C07K 2319/20 (2013.01); C07K 2319/33 (2013.01)]

15 Claims

1. A delivery molecule for transduction of a cargo into a cell comprising:

a cargo, or a cargo-binding molecule for binding to a cargo, and optionally wherein the cargo is bound to the cargo-binding molecule;

a glycosaminoglycan (GAG) binding element comprising:

P21 of Heparin-binding EGF-like growth factor (HB-EGF); or

a GAG binding antibody, which is capable of binding to GAG on the surface of the cell; and

a protein transduction domain (PTD) wherein the PTD is not a heparin binding domain.