CPC A61K 47/548 (2017.08) [A61K 9/16 (2013.01); A61K 9/5115 (2013.01); A61K 9/5123 (2013.01); A61K 9/5192 (2013.01); A61K 47/10 (2013.01); A61K 47/6923 (2017.08); A61P 35/00 (2018.01); C12N 15/88 (2013.01); A61K 45/06 (2013.01); A61K 2300/00 (2013.01); B82Y 5/00 (2013.01)] | 11 Claims |
1. A bone-cell targeting mesoporous silica nanoparticle (MSNP), the MSNP comprising a silane coating comprising a plurality of water soluble bisphosphonate moieties linked to the coating, and optionally further comprising at least one cargo selected from the group consisting of at least one non-bisphosphonate anticancer agent, a reporter, and a combination thereof, wherein the bone-cell targeting MSNP is prepared by
(a) contacting a water soluble bisphosphonate and an epoxysilane to provide a water soluble bisphosphonate moiety linked to the silane; and
(b) combining the water soluble bisphosphonate moiety linked to the silane with MSNPs and a zwitterionic silane to provide for silane coated MSNP comprising a plurality of the water soluble bisphosphonate moieties linked to the coating,
wherein the bisphosphonate has the structure
or a salt or Ionic form thereof,
wherein R1 Is H, OH, or halogen, and R2 is —NH2 or a C1-C6 monoalkyl amine.
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