US 11,672,866 B2
Osteotropic nanoparticles for prevention or treatment of bone metastases
Paul N. Durfee, Albuquerque, NM (US); Charles Jeffrey Brinker, Albuquerque, NM (US); Yu-Shen Lin, Seattle, WA (US); and Hon Leong, London (CA)
Appl. No. 16/68,235
Filed by Paul N. Durfee, Albuquerque, NM (US); Charles Jeffrey Brinker, Albuquerque, NM (US); Yu-Shen Lin, Seattle, WA (US); and Hon Leong, London (CA)
PCT Filed Jan. 6, 2017, PCT No. PCT/US2017/012583
§ 371(c)(1), (2) Date Jul. 5, 2018,
PCT Pub. No. WO2017/120504, PCT Pub. Date Jul. 13, 2017.
Claims priority of provisional application 62/395,196, filed on Sep. 15, 2016.
Claims priority of provisional application 62/276,388, filed on Jan. 8, 2016.
Claims priority of provisional application 62/276,297, filed on Jan. 8, 2016.
Prior Publication US 2019/0022235 A1, Jan. 24, 2019
Int. Cl. A61K 47/54 (2017.01); A61K 9/51 (2006.01); A61P 35/00 (2006.01); A61K 9/16 (2006.01); B82Y 5/00 (2011.01); A61K 47/69 (2017.01); C12N 15/88 (2006.01); A61K 47/10 (2017.01); A61K 45/06 (2006.01)
CPC A61K 47/548 (2017.08) [A61K 9/16 (2013.01); A61K 9/5115 (2013.01); A61K 9/5123 (2013.01); A61K 9/5192 (2013.01); A61K 47/10 (2013.01); A61K 47/6923 (2017.08); A61P 35/00 (2018.01); C12N 15/88 (2013.01); A61K 45/06 (2013.01); A61K 2300/00 (2013.01); B82Y 5/00 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A bone-cell targeting mesoporous silica nanoparticle (MSNP), the MSNP comprising a silane coating comprising a plurality of water soluble bisphosphonate moieties linked to the coating, and optionally further comprising at least one cargo selected from the group consisting of at least one non-bisphosphonate anticancer agent, a reporter, and a combination thereof, wherein the bone-cell targeting MSNP is prepared by
(a) contacting a water soluble bisphosphonate and an epoxysilane to provide a water soluble bisphosphonate moiety linked to the silane; and
(b) combining the water soluble bisphosphonate moiety linked to the silane with MSNPs and a zwitterionic silane to provide for silane coated MSNP comprising a plurality of the water soluble bisphosphonate moieties linked to the coating,
wherein the bisphosphonate has the structure

OG Complex Work Unit Chemistry
or a salt or Ionic form thereof,
wherein R1 Is H, OH, or halogen, and R2 is —NH2 or a C1-C6 monoalkyl amine.