US 11,672,861 B2
Prussian blue nanoparticles functionalized with immune signals and applications thereof
Rohan Fernandes, Bethesda, MD (US); Elizabeth Sweeney, Washington, DC (US); and Juliana Cano-Mejia, Arlington, VA (US)
Assigned to The George Washington University, Washington, DC (US)
Filed by The George Washington University, Washington, DC (US)
Filed on Mar. 19, 2019, as Appl. No. 16/358,468.
Claims priority of provisional application 62/745,843, filed on Oct. 15, 2018.
Prior Publication US 2020/0114005 A1, Apr. 16, 2020
Int. Cl. A61K 41/00 (2020.01); A61K 33/26 (2006.01); A61K 31/7088 (2006.01); A61K 9/51 (2006.01); A61N 5/06 (2006.01); A61B 5/00 (2006.01); A61B 5/055 (2006.01); A61K 9/50 (2006.01); A61K 38/19 (2006.01); A61B 6/00 (2006.01); A61B 8/08 (2006.01)
CPC A61K 41/0052 (2013.01) [A61B 5/0071 (2013.01); A61B 5/055 (2013.01); A61B 6/481 (2013.01); A61B 8/481 (2013.01); A61K 9/5052 (2013.01); A61K 9/51 (2013.01); A61K 31/7088 (2013.01); A61K 33/26 (2013.01); A61K 38/19 (2013.01); A61N 5/062 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A biofunctionalized nanocomposite, comprising:
(a) a core comprising Prussian blue materials;
(b) a positively charged biocompatible coating comprising polyethylenimine (PEI) having an average molecular weight (MW) of about 2000 daltons; and
at least one CpG oligodeoxynucleotide attached to the outer surface of the positively charged biocompatible coating.