CPC A61K 31/519 (2013.01) [A61K 39/0008 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01)] | 6 Claims |
1. A method of increasing the percentage of B regulatory cells in the B cell population in a subject in need of treatment with a therapeutic, comprising administering to the subject an effective amount of methotrexate, thereby increasing said percentage in said subject, wherein the subject is administered a therapeutic for more than one cycle of a dosing regimen, wherein the therapeutic is human acid alpha-glucosidase, wherein the effective amount of methotrexate is administered in a single cycle of the dosing regimen of the therapeutic, and wherein methotrexate is not administered in subsequent cycles of the dosing regimen of the therapeutic.
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