US 11,672,800 B2
Combination therapies with EHMT2 inhibitors
John Emmerson Campbell, Cambridge, MA (US); Kenneth William Duncan, Westwood, MA (US); Maria Alejandra Raimondi, Jamaica Plain, MA (US); Christine Klaus, Waban, MA (US); and Elayne Penebre, Auburndale, MA (US)
Assigned to Epizyme, Inc., Cambridge, MA (US)
Appl. No. 16/606,833
Filed by Epizyme, Inc., Cambridge, MA (US)
PCT Filed Apr. 20, 2018, PCT No. PCT/US2018/028609
§ 371(c)(1), (2) Date Oct. 21, 2019,
PCT Pub. No. WO2018/195450, PCT Pub. Date Oct. 25, 2018.
Claims priority of provisional application 62/574,147, filed on Oct. 18, 2017.
Claims priority of provisional application 62/488,679, filed on Apr. 21, 2017.
Prior Publication US 2020/0054635 A1, Feb. 20, 2020
Int. Cl. A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61P 35/00 (2006.01); A61K 31/203 (2006.01); A61K 31/4375 (2006.01); A61K 31/44 (2006.01); A61K 31/496 (2006.01); A61K 31/517 (2006.01); A61K 31/519 (2006.01); A61K 31/706 (2006.01)
CPC A61K 31/506 (2013.01) [A61K 31/203 (2013.01); A61K 31/4375 (2013.01); A61K 31/44 (2013.01); A61K 31/496 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 31/706 (2013.01); A61P 35/00 (2018.01)] 20 Claims
OG exemplary drawing
 
1. A method for treating an acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), or melanoma comprising administering to a subject in need thereof a compound selected from:

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or a pharmaceutically acceptable salt thereof,
and one or more additional therapeutic agent selected from a PI3K inhibitor, a MTOR inhibitor, an AKT inhibitor, a BRAF inhibitor, a MEK1 inhibitor, a MEK2 inhibitor, an ERK inhibitor, an EGFR inhibitor, a DNMT inhibitor, a cKIT inhibitor, and a CDK4/6 inhibitor, or any combination thereof.