US 11,672,789 B2
Radiation mitigator and method of use thereof
Milton L. Brown, Brookeville, MD (US); Yali Kong, Fairfax, VA (US); Courtney Houchen, Edmond, OK (US); Sripathi M. Sureban, Oklahoma City, OK (US); and Parthasarathy Chandrakesan, Edmond, OK (US)
Assigned to Georgetown University, Washington, DC (US); and The Board of Regents of the University of Oklahoma, Norman, OK (US)
Filed by Georgetown University, Washington, DC (US); and The Board of Regents of the University of Oklahoma, Norman, OK (US)
Filed on Apr. 25, 2022, as Appl. No. 17/728,485.
Application 17/728,485 is a continuation of application No. 16/089,794, granted, now 11,311,526, previously published as PCT/US2017/025440, filed on Mar. 31, 2017.
Claims priority of provisional application 62/316,121, filed on Mar. 31, 2016.
Prior Publication US 2023/0033749 A1, Feb. 2, 2023
Int. Cl. A61K 31/454 (2006.01); A61P 39/00 (2006.01); A61K 31/4184 (2006.01)
CPC A61K 31/454 (2013.01) [A61K 31/4184 (2013.01); A61P 39/00 (2018.01)] 18 Claims
 
1. A method for treating or preventing radiation-induced tissue injury, comprising co-administering to a subject in need thereof a therapeutically effective amount of a compound represented by formula II

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of a compound represented by formula III

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, thereby treating or preventing radiation-induced tissue injury in the subject.