CPC A61K 31/422 (2013.01) [A61K 31/4155 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01)] | 15 Claims |
1. A method of treating a disorder or disease in a subject, wherein the subject has the disorder or disease, wherein the disease or disorder is selected from Pulmonary Hypertension, Fibrosis, Rheumatoid Arthritis, and Fracture healing, the method comprising administering to the subject a therapeutically effective amount of a compound of formula (I):
or a pharmaceutically acceptable salt thereof, wherein
R1 is (C3-C6)alkyl or (C3-C6)cycloalkyl;
R2 is methyl;
R3 is selected from (C6-C10)branched alkyl, (C6-C10)branched alkenyl, (C5-C8)cycloalkenyl, (C5-C8)cycloalkyl, or Het; wherein the (C5-C8)cycloalkenyl or (C5-C8)cycloalkyl is unsubstituted or is substituted by one, two, three or four substituents R4; and wherein Het is substituted by one, two, three or four substituents R4;
each R4 is independently selected from halo, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, or halo(C1-C4)alkoxy; or
two R4 groups, when attached to the same carbon atom, may be taken together with the carbon atom to which they are attached to form a cyclopentyl, tetrahydrofuran or dioxolane ring; wherein Het is a 5 or 6 membered fully saturated or partially saturated heterocyclic ring comprising a) 1 oxygen atom in the 2- or 3-position, or b) 2 oxygen atoms in the 2- and 5-, or 2- and 6-positions, wherein the numbering is relative to the point of attachment; and
(C5-C8)cycloalkyl may be a monocyclic ring or a bridged ring system containing 5, 6, 7 or 8 carbon atoms.
|