US 11,672,775 B2
Treprostinil prodrugs
Ken Phares, Hillsborough, NC (US); Hitesh Batra, Herndon, NC (US); Liang Guo, Vienna, VA (US); and Adam Marc Silverstein, Cary, NC (US)
Assigned to United Therapeutics Corporation, Silver Spring, MD (US)
Filed by United Therapeutics Corporation, Silver Spring, MD (US)
Filed on Jan. 4, 2021, as Appl. No. 17/140,705.
Application 17/140,705 is a continuation of application No. 15/716,007, filed on Sep. 26, 2017, abandoned.
Claims priority of provisional application 62/399,737, filed on Sep. 26, 2016.
Prior Publication US 2021/0121433 A1, Apr. 29, 2021
Int. Cl. A61K 31/27 (2006.01); A61K 31/216 (2006.01); A61K 31/335 (2006.01); A61K 31/222 (2006.01); A61P 9/12 (2006.01); A61K 9/00 (2006.01); A61K 31/192 (2006.01); A61K 31/265 (2006.01)
CPC A61K 31/27 (2013.01) [A61K 9/0019 (2013.01); A61K 31/192 (2013.01); A61K 31/216 (2013.01); A61K 31/222 (2013.01); A61K 31/265 (2013.01); A61K 31/335 (2013.01); A61P 9/12 (2018.01)] 6 Claims
 
1. A compound having the formula:

OG Complex Work Unit Chemistry
wherein X is OH, R2 and R3 are the same and are

OG Complex Work Unit Chemistry
wherein Y is NR4R5, wherein each of R4 and R5 is independently selected from H and C1-4 alkyl.