CPC A61K 9/5146 (2013.01) [A61K 9/513 (2013.01); A61K 38/005 (2013.01); A61K 38/10 (2013.01); A61K 47/595 (2017.08); A61K 47/60 (2017.08); C07K 7/08 (2013.01); C07K 17/06 (2013.01); C07K 17/08 (2013.01)] | 20 Claims |
1. A unimolecular nanoparticle comprising:
a dendritic polymer core having a molecular weight of 500 to 120,000 Da and terminating in hydroxyl, amino or carboxylic acid groups;
anionic polymers attached to at least a majority of the terminating groups of the dendritic polymer, wherein
each anionic polymer comprises a polymeric backbone attached to weakly basic groups by a C2-C12 heteroalkyl group comprising 1 to 4 nitrogen atoms and anionic functional groups, wherein
the anionic functional groups are each conjugated to the polymeric backbone via a pH sensitive linker and optionally the C2-C12 heteroalkyl group,
the number of anionic functional groups per repeat unit of the anionic polymer ranges from 1-2 and the number of weakly basic groups per repeat unit of the anionic polymer ranges from 0 to 2, and
each anionic polymer has a molecular weight from about 1,000 to about 10,000 Da; and
poly(ethylene glycol) attached to a plurality of anionic polymers and having a terminal group selected from a targeting ligand, OH, O-alkyl, NH2, biotin, or a dye, wherein the poly(ethylene glycol) has a molecular weight of about 1,000 to about 15,000 Da.
|