US 11,672,766 B2
Therapeutic cationic peptides and unimolecular nanoparticles for efficient delivery thereof
Shaoqin Gong, Madison, WI (US); Wei Xu, Middleton, WI (US); Yuyuan Wang, Madison, WI (US); and Fabao Liu, Madison, WI (US)
Assigned to Wisconsin Alumni Research Foundation, Madison, WI (US)
Filed by Wisconsin Alumni Research Foundation, Madison, WI (US)
Filed on Apr. 10, 2020, as Appl. No. 16/845,938.
Application 16/845,938 is a division of application No. 15/892,140, filed on Feb. 8, 2018, granted, now 10,660,860.
Claims priority of provisional application 62/456,477, filed on Feb. 8, 2017.
Prior Publication US 2020/0276130 A1, Sep. 3, 2020
Int. Cl. A61K 9/14 (2006.01); A61K 38/03 (2006.01); A61K 9/51 (2006.01); A61K 38/10 (2006.01); A61K 38/00 (2006.01); C07K 7/08 (2006.01); C07K 17/06 (2006.01); A61K 47/59 (2017.01); A61K 47/60 (2017.01); C07K 17/08 (2006.01)
CPC A61K 9/5146 (2013.01) [A61K 9/513 (2013.01); A61K 38/005 (2013.01); A61K 38/10 (2013.01); A61K 47/595 (2017.08); A61K 47/60 (2017.08); C07K 7/08 (2013.01); C07K 17/06 (2013.01); C07K 17/08 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A unimolecular nanoparticle comprising:
a dendritic polymer core having a molecular weight of 500 to 120,000 Da and terminating in hydroxyl, amino or carboxylic acid groups;
anionic polymers attached to at least a majority of the terminating groups of the dendritic polymer, wherein
each anionic polymer comprises a polymeric backbone attached to weakly basic groups by a C2-C12 heteroalkyl group comprising 1 to 4 nitrogen atoms and anionic functional groups, wherein
the anionic functional groups are each conjugated to the polymeric backbone via a pH sensitive linker and optionally the C2-C12 heteroalkyl group,
the number of anionic functional groups per repeat unit of the anionic polymer ranges from 1-2 and the number of weakly basic groups per repeat unit of the anionic polymer ranges from 0 to 2, and
each anionic polymer has a molecular weight from about 1,000 to about 10,000 Da; and
poly(ethylene glycol) attached to a plurality of anionic polymers and having a terminal group selected from a targeting ligand, OH, O-alkyl, NH2, biotin, or a dye, wherein the poly(ethylene glycol) has a molecular weight of about 1,000 to about 15,000 Da.