CPC A61K 9/1075 (2013.01) [A61K 9/0048 (2013.01); A61K 31/05 (2013.01); A61K 31/44 (2013.01); A61K 31/5575 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/14 (2013.01); A61K 47/26 (2013.01); A61K 47/44 (2013.01); A61P 27/02 (2018.01); A61P 27/04 (2018.01)] | 40 Claims |
1. A pharmaceutical composition that is an oil-in-water microemulsion, comprising:
a) a lipid phase comprising an oily component, one or more surfactant(s), and one or more co-surfactant(s);
b) an aqueous phase comprising one or more surfactant(s), and one or more co-surfactant(s); and
c) a pharmaceutically active compound, wherein:
the weight/volume ratio between the total amount of surfactant and co-surfactant in the lipid phase to the total amount of surfactant and co-surfactant in the aqueous phase is from 2 to 10;
the weight/volume ratio between the amount of oily component in the lipid phase to the total amount of surfactant and co-surfactant in the aqueous phase is from 0.2 to 1.0; and
in the resulting oil-in-water microemulsion, the average particle size is less than 30 nm and the polydispersity index (PDI) is within the range 0.02-0.380, inclusive.
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